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1.
Journal of Experimental Hematology ; (6): 904-908, 2020.
Artículo en Chino | WPRIM | ID: wpr-827187

RESUMEN

OBJECTIVE@#To evaluate the characteristics of autoimmune hemolytic anemia caused by salvianolate by antibody detection and clinical index monitoring.@*METHODS@#Micro-column gel anti-human globulin method was used for irregular antibody screening and antibody identification. Salvianolate, sodium creatine phosphate and levocarnitine were used to sensitize red blood cells that were compatible with the patient's plasma, and the RBCs were used to test drug antibody in patient plasma respectively. The patient's clinical examination of hemolysis index and blood transfusion effect were analyed retrospectively.@*RESULTS@#The patients were positive for irregular antibody screening, and there were antoanti-Ce antibodies in serum. The erythrocytes sensitized with salvianolate in the patient's serum were positive, while those sensitized with sodium creatine phosphate and levocarnitine were negative.@*CONCLUSION@#Salvianolate causes drug-induced autoimmune hemolytic anemia in this patient.


Asunto(s)
Humanos , Anemia Hemolítica Autoinmune , Transfusión Sanguínea , Eritrocitos , Extractos Vegetales , Estudios Retrospectivos
2.
Journal of Zhejiang University. Medical sciences ; (6): 222-228, 2012.
Artículo en Chino | WPRIM | ID: wpr-336804

RESUMEN

Channels from the TRP superfamily have essential roles in a wide variety of sensory transductions, especially in mechano-sensation, such as hearing, touch and mechanical pain. TRP channels are also implicated in major channelopathies, including deafness, chronic pain, autosomal dominant polycystic kidney disease (ADPKD) and ventricular hypertrophy. As the leading candidates for mechano-sensitive channels, some TRP channels appear to be mechano-receptor, which can be activated by mechanical forces directly, such as C. elegans TRPN homolog TRP-4; whereas others may act as signal modulators, receiving and amplifying signals indirectly. This review is to introduce the function of TRPs in mechano-sensory transduction and to discuss the underlying molecular mechanisms.


Asunto(s)
Animales , Humanos , Conducción Nerviosa , Sensación , Fisiología , Transducción de Señal , Canales de Potencial de Receptor Transitorio , Metabolismo , Fisiología
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