RESUMEN
Staphylococcus aureus is one of the most frequently encountered zoonotic pathogens.This bacterium produces the notable virulence factors such as hemolysin,panton-valentine leucocidin,exfoliative toxins and enterotoxin,which can cause invasive disease in humans and animals.Methicillin-resistant S.aureus (MRSA) is a multidrug-resistant bacterium which acquired the staphylococcal chromosome cassette mec (SCCmec).SCCmec is one of the key reasons for the antibiotic resistance of MRSA.As for MRSA resistance,the β-1actam resistance is mediated by mecA gene,and the drug-resistance genes inserted in the variable area of the SCCmec element play an important role in the multidrug resistance of MRSA.In recent years,it has been reported in Europe,North America and other countries that the multidrug resistance MRSA was detected in aquaculture environment and livestock.Besides,MRSA poses a serious threat to public health,and it can colonize and cause invasive disease in humans through aquaculture environment or other ways.This review summarizes drug resistance change of S.aureus and analysis of SCCmec resistance elements,toxicity and prevalence of livestock-associate MRSA,which would have theoretical and practical significance to understand S.aureus drug resistance,SCCmec typing,as well as control and prevent LA-MRSA transmission and infection between animals and humans.