A review of the clinical progress on helminths and their derivative products in autoimmune disease / 细胞与分子免疫学杂志

Traditional medications used for treating autoimmune diseases often come with a wide range of adverse effects. Current treatments focus mainly on symptom management, resulting in significant health issues and financial burdens for patients. Recently, clinical research has demonstrated the potential of helminths and their derivatives as effective therapies for autoimmune disorders. Helminths, being a near-natural immunomodulator, exhibit milder effects than broad-spectrum immunosuppressants and corticosteroids, thereby presenting a promising alternative for the treatment of autoimmune diseases. However, different helminths' therapeutic efficacy and mechanisms and their derivatives in treating autoimmune diseases may vary. Therefore, we aim to review recent clinical advancements in the use of helminths and their derivatives for treating inflammatory bowel disease, multiple sclerosis, and autism spectrum disorder, with a view to offering novel clinical treatment approaches.

Comparison of the clinical value of ultrasonic elastography and common ultrasonic features in diagnosing papillary thyroid carcinoma / 中国基层医药

Objective@#To compare the clinical value of ultrasonic elastography (UE) and three common ultrasonic features in diagnosing papillary thyroid carcinoma (PTC).@*Methods@#From January 2012 to December 2017, the clinical data of 105 cases with PTC which were confirmed by postoperative pathologic examination and 20 cases with benign thyroid nodules (BTN) in the Integration of Chinese and Western Medicine Hospital Affiliated to Nanjing University of Traditional Chinese Medicine were analyzed retrospectively.The UE and common ultrasonic features comprising a taller-than-wide shape, irregular margins and microcalcifications were analyzed.The sensitivity, specificity and area under curve (AUC) of PCT dingnosis with two different ultrasonic parameters are calculated.@*Results@#Based on surgical pathology, the diagnostic sensitivity of irregular boundary is the highest amony the three paraneters of ordinary ultrasound.Although an irregular margin showed higher sensitivity than taller-than-wide shape and microcalcifications with 71.42% vs.59.04% vs.60.00%, but there was no statistically significant difference (χ2=4.3, P=0.116). There was also no statistically significant difference in specificity (χ2=0.134, P=0.935). The diagnostic efficiency of UE was higher than taller-than-wide shape (Z=3.046, P=0.002), irregular margin(Z=2.962, P=0.003) as well as microcalcifications(Z=3.942, P=0.000), the difference was statistically significant(P<0.05). The diagnostic efficiency of UE was higher than the combined three common ultrasonic features together (Z=3.125, P=0.001).@*Conclusion@#UE score shows a higher diagnostic efficiency, easy to perform, indicating the important application value in preoperative diagnosis of PTC, and is worthy of promoting in clinic.

Comparison of the clinical value of ultrasonic elastography and common ultrasonic features in diagnosing papillary thyroid carcinoma / 中国基层医药

Objective To compare the clinical value of ultrasonic elastography ( UE) and three common ultrasonic features in diagnosing papillary thyroid carcinoma ( PTC).Methods From January 2012 to December 2017,the clinical data of 105 cases with PTC which were confirmed by postoperative pathologic examination and 20 cases with benign thyroid nodules (BTN) in the Integration of Chinese and Western Medicine Hospital Affiliated to Nanjing University of Traditional Chinese Medicine were analyzed retrospectively.The UE and common ultrasonic features comprising a taller -than-wide shape,irregular margins and microcalcifications were analyzed.The sensitivity, specificity and area under curve ( AUC) of PCT dingnosis with two different ultrasonic parameters are calculated. Results Based on surgical pathology ,the diagnostic sensitivity of irregular boundary is the highest amony the three paraneters of ordinary ultrasound.Although an irregular margin showed higher sensitivity than taller -than -wide shape and microcalcifications with 71.42% vs.59.04% vs.60.00%,but there was no statistically significant difference (χ2 ＝4.3,P＝0.116).There was also no statistically significant difference in specificity (χ2 ＝0.134,P＝0.935). The diagnostic efficiency of UE was higher than taller -than-wide shape (Z＝3.046,P＝0.002),irregular margin (Z＝2.962,P＝0.003) as well as microcalcifications (Z＝3.942,P＝0.000),the difference was statistically signifi-cant(P＜0.05).The diagnostic efficiency of UE was higher than the combined three common ultrasonic features together (Z＝3.125,P＝0.001).Conclusion UE score shows a higher diagnostic efficiency ,easy to perform, indicating the important application value in preoperative diagnosis of PTC ,and is worthy of promoting in clinic.

Formation mechanism of hypercoagulable state after radiofrequency ablation for atrial fibrillation / 心血管康复医学杂志

Pulmonary vein isolation (PVI) is a new ,effective and radical method to cure atrial fibrillation .Within a period after radiofrequency ablation (RFA) ,coagulation system is activated in patients ,then thrombus incident such as cerebral embolism may happen .The present article made a review on its mechanism .