Effect of nalmefene hydrochloride adjuvant therapy on serum NO, endothelin and cardiac troponin I in patients with traumatic shock / 中国生化药物杂志

Objective To analyse effect of nalmefene hydrochloride adjuvant therapy on serum nitric oxide(NO), endothelin (ET) and cardiac troponin I ( cTnI) in patients with traumatic shock.Methods 48 patients who were diagnosed with traumatic shock were collected.All patients were randomly divided into experimental group and control group, 24 cases in each group.On the basis of conventional anti shock treatment, the control group were treated with naloxone, the patients in experimental group received nalmefene hydrochloride treatment, after treatment, the serum levels of NO, endothelin and cardiac troponin I were detected in all patients.Results After treatment, compared with control group, the serum level of NO was lower in experimental group(P<0.05);the serum level of ET was lower in experimental group(P<0.05);the serum level of cTnI was lower in experimental group(P<0.05).Conclusions Nalmefene hydrochloride adjuvant therapy could significantly reduce the serum levels of NO, ET and cTnI in patients with traumatic shock,control the development of the disease, prevent myocardial injury.

Clinical research on subcutaneous drainage tube in the prevention of abdominal surgical incision infection / 中国基层医药

Objective To observe the clinical effect of subcutaneous drainage tube in the prevention of abdominal surgical incision infection.Methods According the admission sequence,290 abdominal surgery patients were selected and randomly divided into the two groups,each group 145 cases.The patients of the observation gronp were placed subcutaneous drainage tube after operation,and the patients of the control group were not placed subcutaneous drainage tube.The wound healing,wound infection rate,and secondary debridement incidence of the two groups were observed and compared.Results The successful surgery were in 190 patients,and there was no patient in death.The incision healing rate of first grade in the observation group was 97.93％,which in the control group was 89.66％,The incision infection was in 3 cases (2.07％),which in the control group was 12 cases (8.28％).There were all statistically significant differences between the two group (all P ＜ 0.05).The secondary debridement of the observation group was in one case,which in the control group was in 7 cases,and the secondary debridement incidence of the observation group was significantly lower than that of the control group(P ＜ 0.05).Conclusion Placing the subcutaneous drainage tube for abdominal surgery patients can reduce the occurrence of wound infection and secondary debridement,and beconducive to postoperative recovery.