Research progress on chronic disease management / 预防医学

@#Recently,the incidence of chronic disease has been increasing rapidly every year,which contributes to heavy burdens on society. Chronic disease management（CDM）has become an effective solution. At present,CDM in China is still at an early age,without a widely accepted and efficient model for lack of theoretic and practical support. By analyzing and comparing CDM models in China and abroad,we summarizes that CDM in China needs to be guaranteed by government and law,strengthened by the construction of medical team,promoted by an integrated service network,and implemented by hierarchical diagnosis and treatment of multi-departments.

FURTHER STUDIES ON THE DIAGNOSIS OF SCHISTOSOMJASIS JAPONICA BY INDIRECT FLUORESCENT ANTIBODY TEST AND IMMUNOENZYMATIC STAINING TECHNIQUE / 中国血吸虫病防治杂志

Both indirect fluorescent antibody test (IFAT) and immunoenzymatic staining technique(IEST) were used as methods for the comparable detections of 200 cases of patients with schistosomiasis japonica and 100 healthy individuals. The average positive rate in schistosomiasis cases is 99% with both tests, while the false positive rate in healthy individuals is 5% with the former and 3% with the latter. When 322 cases of other parasitic infections and patients with medical diseases were tested by IFAT and IEST, cross-reaction was observed only in clon-orchiasis, fasciolopsiasis and paragonimiasis, 4-6% with IFAT and 0-4% with IEST respectively. 87.6-93.7% showed negative reaction to both tests in schistosomiasis patients during different stages after treatment. It is considered that IFAT and IEST are effective means of serological diagnosis of schistosomiasis japonica, while IEST can be applied suitably in tbe fields for practical purposes.

COMPARISON OF IMMUNOENZYMATIC STAINING TECHNIQUE (IEST), DOUBLE GLUING STRIP CIRCUMOVAL PRECIPITIN TEST(DGS-COPT) AND CONVENTIONAL CIRCUMOVAL PRECIPITIN TEST(CV-COPT) FOR DIAGNOSIS OF SCHISTOSOMIASIS JAPONICA / 中国寄生虫学与寄生虫病杂志

IEST, DGS-COPT and CV-COPT using lyophilized ova of schistosoma japonicum were performed on sera from 120 cases of schistosomiasis japonica, 120 cases of schis-tosomiasis japonica 3-8 years after being cured with praziquantel and 120 healthy individuals by single-blind method. The sensitivity and specificity of IEST was 91.7% and 95.8% respectively which were significantly higher than that of both DGS-COPT and CV-COPT. The negative conversion rate of cured patients was 70.8% with IEST, 80.8% with DGS-COPT and 81.7% with CV-COPT. The results showed that IEST has higher diagnostic value for schistosomiasis than both COPT. DGS-COPT has the same diagnostic value as CV-COPT, however, it was easy to perform and time-saving, thus it might be applied in the fields for practical purposes.

STUDIES ON THE DIAGNOSIS OF HUMAN FILARIASIS BY INDIRECT FLOURESCENT ANTIBODY TEST(IFAT) AND IMMUNOENZYMATIC STAINING TECHNIQUE(IEST) WITH HOMOLOGOUS AND HETEROLOGOUS ADULT FILARIAL ANTIGENS / 中国寄生虫学与寄生虫病杂志

This article deals with the diagnostic values of IFAT and IEST in human filariasis with both frozen sections of Brugia malayi and Setaria cervi adult worms as antigens. The average positive and the false positive rates of IFAT with two antigens were 84.9-97.1%(45/53-102/105)and 2.9-9.7%(1/35-3/31) respectively, while no cross-reaction was observed in subjects infected with ascaris or hookworm. The average positive and the false positive rates of IEST with two antigens were 94.3-94.9% (99/105-56/59) and 0-2.9% (0/35-l/35) respectively. Both IFAT and IEST with two antigens for the diagnosis of human filariasis were considered to be of higher sensitivity and specificity, frozen sections of adult Setaria cervi being more economical and effective.