Involvement of sympathetic nervous system in the pathogenesis of hypertension / 中华医学遗传学杂志

Sustained activation of sympathetic nervous system in response to stimulation of a wide variety of stress factors is an independent risk factor for the development of essential hypertension. Adrenal hormone biosynthesis pathway as an important part of the sympathetic nervous system consists of hormones, neurotransmitters, receptors, and a variety of synthases and invertases. In this article, we have systematically reviewed research progresses made in elucidating the interactions between genes of the adrenal hormone biosynthesis pathway and stress factors in the pathogenesis of essential hypertension.

Association of ER22/23EK polymorphism in glucocorticoid receptor gene with natural longevity in Xinjiang Uygur nationality and comparison with Han nationality / 基础医学与临床

Objective To investigate association of the ER22/23EK polymorphism of the glucocorticoid receptor gene(GR) with natural longevity in the XinJiang Uygur nationality people and the race difference.Methods One hundred and nintyone healthy individuals over 90 years old from Uighur people were recruited as the longevity group at the same time,82 Han nationality people aged between 65～70 who immigrated in Xinjiang Hetian for more than 30 years were randomly selected and investigated.Genotyping was performed by PCR-SSP,PCR-RELP and PCR-sequencing.ResultsThe frequencies of ER22/23EK alleles and genotypes showed no significant difference between the longevity group and the controls in Uygur,but the carriers of ER22/23EK of GR gene in Xinjiang Han old folkswere significantly more than those in Uygurs,the frequencies of WM, MM genotypes and M allele were significantly higher in Han nationality,while the frequencies of WW genotype and W allele were significant lower.Conclusion There is possibly no association between ER22/23EK polymorphism and XinJiang Uygur natural longevity,but there are significant differences between the two ethnic groups.