RESUMEN
Systemic lupus erythematosus (SLE) is a rheumatic illness that often affects pregnancy outcome of young women of reproductive age.Preeclampsia is a common gestational complication.SLE flare during pregnancy and preeclampsia share common clinical features,such as hypertension,proteinuria,and thrombocytopenia,making differentiation between these two conditions difficultly.The signs and symptoms of new-onset SLE during pregnancy or postpartum may mimic those of preeclampsia,while SLE associated arthritis/arthralgia,alopecia,and ulceration were less commonly found comparing with those non-pregnant patients.SLE is a risk factor for preeclampsia and both affect maternal and fetal outcomes.Changes in angiogenic factors precede the onset of preeclampsia in SLE pregnancies.Low-dose aspirin may decrease the risk for preeclampsia in pregnant women with SLE.Pregnant women should be treated for SLE flare rather than for preeclampsia for the better of the mother and baby when it is difficult to differentiate between these two conditions.
RESUMEN
Objective To describe the clinicopathological features of histiocytic necrotizing lymphadenitis ( HNL). Methods Routine lymph node biopsies of 10 HNL cases were reviewed and their immunophenotyping were performed using S-P immunohistochemical staining. Results Histologically, HNL had discrete or integrated nodules variable in size in the paracortex,expecially in the interfollicular area,which were full of proliferating pleomorphic histocytes,transformed lymphocytes,and karyorrhectic debris without infiltration of the neutrophils, plasma cells and/or eosinophils. Immunohistochemistry revealed CD45RO + for transformed lymphocytes,CD68 +for histiocytes.and CD20 +for lymphocytes in the residual germinal centers. Conclusion The presence of pleomorphic histiocytes, transformed T-cells, and karyor-rhectic debris in the biopsy of lymph nodes, together with the absence of neutrophils support the diagnosis of HNL.