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Objective To study the correlation between coagulation factor Ⅴ Leiden mutation and ischemic stroke in Chinese young adults. Methods From July 2016 to January 2018, 80 young patients with ischemic stroke (18-45 years) admitted to the Department of Neurology, the First Affiliated Hospital of Shantou University Medical College and 80 controls were enrolled prospectively. The demographic data, vascular risk factors were documented. Sanger sequencing was used to detect factor Ⅴ Leiden mutation. Results The 1691 sites of factor Ⅴ genes in the case group and control group were all wild types. Multivariate logistic regression analysis suggested that hypertension ( odds ratio [ OR ] 4. 308, 95％ confidence interval [CI] 3. 321-5. 067; P = 0. 001), hyperlipidemia (OR 2. 734, 95％ CI 2. 214-3. 378; P = 0. 005), and smoking (OR 5. 293, 95％ CI 3. 003-6. 180; P = 0. 010) were the independent risk factors for ischemic stroke in young adults, and high-density lipoprotein cholesterol (OR 0. 611, 95％ CI 0. 457-0. 709; P = 0. 027) was its independent protective factor. Conclusion Factor Ⅴ Leiden mutation is not associated with ischemic stroke in Chinese young adults. Hypertension, dyslipidemia and smoking are still the main risk factors for ischemic stroke in young adults.
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Objective To evaluate the clinical characterization and therapy efficacy on early epilepsy patients after viral encephalitis.Methods To analyze eighty-two early epilepsy patients after viral encephalitis about their onset of illness age,epileptic type,infarction locus and therapy efficacy.Results Early epilepsy patients after viral encephalitis patient's condition and incidence is associated with severity of viral encephalitis and complication.Conclusion To ef- fectively control the patient's condition of viral encephalitis and complication is associated with onset of epilepsy.
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OBJECTIVE:To observe the effect of Alprostadil in reducing24-hour-output of urinary albumin in diabetic patients with cerebral infarction.METHODS:56cases of diabetic patients with cerebral infaraction were randomly divided into treatment group(30cases)and control group(26cases);the control group were given the routine treatment,i.e.compound Danshen and Shengmai,for the treatment group,besides the routine treatment as stated in the control group,were given20?g Alprostadil that dispensed in100ml normal saline(NS)by intravenous drip,qd,for15days and then evaluated ef?fect.RESULTS:The therapeutic effect of the treatment group is better than that of the control group.Compared with that before treatment and that of the control group after treatment,the treatment group showed a lower level of24-hour-output of urinary albumin after treatment(P