RESUMEN
Objective To explore the clinical effect and safety of oxycodone hydrochloride in the induction of genenral anesthesia.Methods Sixty ASA Ⅰ or Ⅱ patients aged 35-75 years,sched-uled for colorectal surgery,undergoing general aneasthesia were randomly divided into two groups with 30 cases in each group:fentanyl group (group F)and oxycodone hydrochloride group (group O).Fentanyl 2 μg/kg+propofol 2 mg/kg+cisatracurium 0.1 5 mg/kg (group F)or oxycodone 0.2 mg/kg+propofol 2 mg/kg + cisatracurium 0.1 5 mg/kg (group O)was administered intravenously for general anesthesia induction.MAP and HR were monitored and recorded before the induction (T0 ),1 min before intubation (T1 ),at the time of intubation (T2 ),1 min after intubation (T3 )and 5 min after intubation (T4 ).Side-effect incidence of each group,operation time,wakening time,extuba-tion time and visual analogue scale (VAS)were recorded.Results Compared with group F,MAP in group O were lower than that of group F at T1 (P <0.05),while HR between two groups at T0-T4 showed no significant difference.In group F,there were statistical significances in MAP and HR be-tween T1-T3 and T0 ;in group O,there were statistical significances in MAP between T1-T2 and T0 , and HR at T2-T3 was significantly higher than that at T0 (P <0.05).No statistical significance were obtained between two groups in the operation time,wakening time and extubation time.The incidence of cough and the VAS of group O was less than that of group F with statistical significance (P <0.05).Conclusion Oxycodone hydrochloride used for the intubation of general anesthesia is practica-ble.