Correlation of 4- and 24-hour urine protein in women with initially diagnosed hypertensive disorders in pregnancy.

OBJECTIVE: To determine whether 4-hour urine protein value correlates with 24-hour urine protein value in women with hypertensive disorders in pregnancy. STUDY DESIGN: Cross-sectional study was performed in 38 in-patient pregnant women who were initially diagnosed as having hypertensive disorders in pregnancy. Urine samples were collected within 24 hours in 2 successive periods: the first 4-hour and the next 20-hour urine, in separate containers. The urine volume, urine protein and creatinine concentrations were thus separately measured. The 4- and 24-hour urine proteins were calculated and the correlation between both groups was determined by simple linear regression analysis. RESULTS: A total of 38 patients were recruited into the study, 26 had mild preeclampsia, 5 had severe preeclampsia, and 7 had superimposed preeclampsia. The result of the 4-hour urine protein was found to correlate with those of the 24-hour urine protein for patients with hypertensive disorders in pregnancy (p < 0.001). CONCLUSION: Total protein values of 4-hour samples positively correlated with values of 24-hour samples of patients with hypertensive disorders in pregnancy. This might be modified and used for urine protein collection in outpatients to improve the compliance.

Correlation between random urinary protein-to-creatinine ratio and quantitation of 24-hour proteinuria in preeclampsia.

OBJECTIVE: To determine whether random urinary protein-to-creatinine ratio correlated with the quantitation of 24-hour proteinuria in cases of preeclampsia. DESIGN: Cross-sectional descriptive study. SUBJECTS: Pregnant patients hospitalized in the obstetric ward, King Chulalongkorn Memorial Hospital due to preeclampsia. METHOD: The random urine specimens were obtained from the eligible subjects for protein-to-creatinine ratio determination, the subjects were then instructed to collect 24-hour urine samples for protein measurement. RESULTS: Twenty-five pregnant patients completed the study. There was a strong correlation between the random urinary protein-to-creatinine ratio and the quantitation of 24-hour proteinuria (r = 0.929, p < 0.001). CONCLUSION: The presented data support a strong correlation between random urinary protein-to-creatinine ratio and quantitation of 24-hour proteinuria in hospitalized pregnant patients with preeclampsia.