RESUMEN
Whether the hepatic pipestem fibrosis induced by schistosomiasis japonica can result in cirrhosis,confusion exists among parasitologists in China.Evidence from national and international pathologists and clinicians confirmed that the pipestem fibrosis could develop into cirrhosis undoubtedly.Owing to different pathogenic causes,the characters of cirrhosis are different.To re-understand cirrhosis induced by schistosomiasis japonica is of significance for the diagnosis and treatment of the advanced patient.
RESUMEN
The effect of gamma interferon on the simulated granuloma formation induced by the eggs of Schistosoma mansoni was observed using a model of SEA-polyacrylamide beads and mouse spleen cells in vitro. The results showed that interferon at the concentration of 0.1~10U/ml could not affect significantly the granulomatous response of the spleen cells of unimmunized mice (Table 1); but at the concentration of 10-100U/ml it could inhibit significantly the response of the spleen cells of immunized mice (Table 2). The mechanism of the inhibition is probably due to the suppression of T helpers in the present study.