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Chinese Journal of Pathology ; (12): 566-568, 2005.
Artículo en Chino | WPRIM | ID: wpr-297290

RESUMEN

<p><b>OBJECTIVE</b>To study the clinicopathologic features and radiologic findings of dysembryoplastic neuroepithelial tumor (DNT).</p><p><b>METHODS</b>The clinical presentations, radiologic findings, histologic features and immunophenotype of 9 cases of DNT were analyzed.</p><p><b>RESULTS</b>The age of patients ranged from 12 to 51 years (mean age = 32 years). Most presented with partial seizures, sometimes accompanied by transient aphasia, agraphia and decreased visual acuity. One case was asymptomatic and discovered incidentally during a routine check-up. All patients had no neurological deficit found on physical examination. All tumors were located in the supratentorial cerebral cortex. There was no peritumoral edema or space-occupying effect on radiologic examination. The tumors involved either frontal lobe (number = 4), temporal lobe (number = 4), frontoparietal lobe (number = 1) . Two cases showed cystic changes. Two histologic variants of DNT were recognized: simple (number = 3) and complex (number = 6). Simple variant was composed mainly of the glioneuronal element, accompanied by surrounding oligodendrocyte-like cells, and the complex variant contained a low-grade glioma component, in addition to the glioneuronal element and sometimes foci of cortical dysplasia.</p><p><b>CONCLUSIONS</b>DNT is a benign tumor with excellent prognosis after surgical excision. Local recurrence is rare. Complex variant of DNT needs to be distinguished from other types of low-grade glioma.</p>


Asunto(s)
Adolescente , Adulto , Niño , Preescolar , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Encefálicas , Metabolismo , Patología , Cirugía General , Corteza Cerebral , Metabolismo , Patología , Epilepsias Parciales , Metabolismo , Patología , Cirugía General , Estudios de Seguimiento , Imagen por Resonancia Magnética , Tumores Neuroectodérmicos Primitivos , Metabolismo , Patología , Cirugía General , Proteínas de Neurofilamentos , Metabolismo , Oligodendroglía , Patología , Proteínas S100 , Metabolismo , Tasa de Supervivencia , Sinaptofisina , Metabolismo
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