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OBJECTIVE: To study the pharmacological function of the petroleum ether extract from Citrullus lanatus vine (PEECLV) in treating adjuvant arthritis(AA) and explore the mechanism. METHODS: AA in mice was made to observe the anti-inflammatory effect of PEECLV. Arthritis index was calculated by 5 grades evaluation. Thymus and spleen index were measured. The content of RF, PGE2, COX-1, COX-2 in serum were measured. The levels of TNF-α, IL-1β in serum were measured. RESULTS: PEECLV can suppress the foot swelling degree in model mice. It can increase thymus index, reduce spleen index and AI of AA in mice. High-dose group can significantly reduce serum PGE2, IL-1β, COX-2 and COX-1 levels in AA in mice. All groups can reduce TNF-α and RF levels. CONCLUSION: PEECLV has a certain degree therapeutic effect on AA, and the possible mechanism is to affect the production of inflammatory mediators and antioxidant.
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OBJECTIVE: To investigate the hypoglycemic effects of different fractions from Citrullus lanatus vine on diabetic model induced by alloxan in mice.
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<p><b>OBJECTIVE</b>To study the changes of palate cleft gap of complete unilateral cleft lip and palate (UCLP) infants before and after presurgical orthodontic and cheiloplasty.</p><p><b>METHODS</b>The sample consisted of 18 complete UCLP infants who were treated using presurgical nasoalveolar molding (PNAM) appliance and cheiloplasty. The maxillary models were obtained at the initial visit, after PNAM treatment 1 month before cheiloplasty, and 2 months after cheiloplasty. The change of palate cleft gap were compared.</p><p><b>RESULTS</b>After PNAM treatment and cheiloplasty, the lip profile was obviously improved, cleft gap was reduced, and the height of ala nasi fornix was recovered.</p><p><b>CONCLUSION</b>PNAM treatment can improve the lip shape and nasal deformity degree of UCLP patient. The cleft gap and upper lip tension are reduced.</p>