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Objective To evaluate the association of the 5'-end dinucleotide repeat polymorphisms of the aldose reductase gene and susceptibility to diabetic nephropathy in Chinese patients with type 2 diabetes mellitus by means of meta analysis. Methods Genetic association studies evaluating the 5'-end dinucleotide repeat polymorphism of the aldose reductase gene and susceptibility to diabetic nephropathy in type 2 diabetes mellitus patients involving Chinese population published before April 2007 were collected from database of PubMed, EMBASE, and CNKI. All the literatures were abstracted based on the defined selection criteria by two independent investigators. Publication bias was tested by funnel plot and the odd ratios of all studies were combined depending on the result of heterogeneity test among the individual studies. The software Review Manager (version 4.2) was used for meta analysis. Results Eight studies involving 5'-end dinucleotide repeat polymorphism of the aldose reductase gene and susceptibility of diabetic nephropathy in Chinese patients with type 2 diabetes mellitus met the selection criteria. There was no significant publication bias in selected studies. Heterogeneity test showed that there were significant statistic differences among the individual studies about the frequencies of Z-2 (χ2=18.20, P= 0.01) and Z + 2 (χ2 = 35.30, P < 0.01) allele in different groups. The combined OR of susceptibility to diabetic nephropathy in patients with Z-2 allele was 1.72 (95% CI 1.25-2.36, P < 0.01) and those of Z + 2 and Z + 6 were 0.73 (95% CI 0.47-1.12, P =0.15) and 0.66 (95%C10.45-0.98, P = 0.04) respectively. Conclusion The 5'-end dinucleotide repeat polymorphism of the aldose reductase gene was associated with the susceptibility of diabetic nephropathy in Chinese patients with type 2 diabetes mellitus. The Z -2 allele is a genetic risk factor for diabetic nephropathy, while the Z + 6 allele has protective function for kidney mierovessels.
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Objective To understand the current status of the serum lipids in the young and middle aged policemen,and to compare the detection rates of hypertension and hyperglycemia among individuals with different lipid levels.Methods Total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and triglyceride(TG)were detected in 1 980 of the young and middle aged policemen by standard methods.Lipid levels and phenotypes of dyslipidemia were classified according to the'Recommended guidelines for prevention and treatment of dyslipidemia'of China(1997).Hypertension and hyperglycemia were defined according to the WHO's standard respectively.The relationship of dyslipidemia with hypertension and hyperglycemia were studied furthermore.Results There were 47.1% of the subjects whose TG and TC levels were in the optimal levels.The detection rates of hypertension and hyperglycemia were 8.4% and 3.6% respectively.The average levels of TC and TG in male aged 31 years old and over were beyond the optimal levels.The levels of fasting blood glucose and blood pressure of those with dyslipidemia were higher than of the normal individuals generally.The detection rates of hyperglycemia and hypertension in subjects with normal serum lipids were 1.5% and 4.2%,in subjects with hypertriglyceridemia were 6.5% and 8.8%,in hypercholesterolemia subjects were 1.7% and 16.1%,and in those subjects with mixed dyslipidemia were 4.7% and 18.7% respectively.Conclusion There was a trend of high prevalence of dyslipidemia,hypertension and hyperglycemia in young policemen.
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0.05). In the non-smoking group, the pulse pressures of patients with coronary heart disease were significantly higher than those of subjects with negative angiographic results. Among the three subgroups with different severity of coronary arterial lesion, the pulse pressure of 3-vessel diseases was higher than those of both 2-vessel and 1-vessel subgroup. The pulse pressure of subjects with negative angiographic results in smoking group was significantly higher than that in non-smoking group [(56.1?17.2) mm Hg vs (50.9?11.4) mm Hg,1 mm Hg=0.133 kPa P
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AIM: To investigate the changes of intrarenal endothelin system in the course of congestive heart failure. METHODS: A canine congestive heart failure model induced by rapid right ventricular pacing was used in the present study. Twenty-one mongrel dogs divided randomly into 3 groups: control, congestive heart failure 2 weeks(CHF2) and congestive heart failure 4 weeks (CHF4). The severity of heart failure was evaluated by means of hemodynamic measurement. The concentration of plasma endothelin was detected via RIA, and the expression of endothelin was detected by RT-PCR. RESULTS: The concentration of plasma endothelin in both of CHF2 and CHF4 elevated significantly. In CHF2, the expression of endothelin receptor B(ETB) in renal medulla increased significantly. And in CHF4, the expression of preproendothelin, endothelin receptor A(ETA) and ETB increased both in renal cortex and medulla. Furthermore, in cortex, the expression of ETA increased more significantly than ETB, while in medulla, ETB expressed much more than ETA. CONCLUSION: The changes of renal endothelin system expression plays a role in the regulation of water and electrolyte balance during the progress of congestive heart failure.
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AIM: To evaluate expression of the components of endothelin system in pulmonary tissue in a canine pacing-induced congestive heart failure model. METHODS: Twenty-one dogs were divided into 3 groups received 2 (pacing 2 group) or 4 weeks (pacing 4 group) rapid right ventricular pacing, respectively, whereas the other group consisted of 7 dogs received sham-operation as control group. Haemodynamic parameters were detected via left and right heart catheterization. Plasma endothelin-1 was determined by means of RIA. In addition, RT-PCR was used to quantify expression of mRNA of components of endothelin system using ?-actin as internal control. One-way ANOVA and linear regression analysis were used for statistical study. RESULTS:Plasma endothelin-1 increased significantly in heart failure animals. The ratio of preproET-1 to ? actin mRNA was significantly increased from 0.14?0.06 in control group to 0.35?0.08 in pacing 2 group and 0.53?0.08 in pacing 4 group ( P