1.
Chinese Journal of Pathophysiology
;
(12)1989.
Artículo
en Chino
| WPRIM
| ID: wpr-519242
RESUMEN
AIM:To investigate the effect of lansoprazole on gastric ulceration in rats. METHODS:Using the gastric ulcer model induced by hemorrhagic shock, restraint water-immersion stress and pylorus-ligature, the protective effect of lansoprazole (iv) on gastric ulceration was observed. RESULTS: Pretreatment with lansoprazole (7.5-60 mg/kg) significantly inhibited the formation of gastric ulcer in the three models in a dose-dependent manner. The autiulcer efficacy of lansoprazole was similar to that of omeprazole in the equal dose, but stronger than that of omeprazole for ulcer induced by water-immersion stress. CONCLUSION: The intravenously administered lansoprazole inhibited formation of experimental gastric ulcer in rats.