RESUMEN
Objective:To investigate the value of computational omics biology model (CBM) in treatment of refractory acute myeloid leukemia (AML) patients.Methods:The clinical data of a refractory AML patient who received personalized therapy regimen predicted by Cellworks tumor response index (TRI) test in November 2018 were retrospectively analyzed. The diagnosis, treatment and the therapeutic efficacy were summarized. The literature related to CBM in AML was reviewed.Results:The patient, a 43-year-old female, was diagnosed as AML accompanied with t(6;11)(q27;q23). She failed to respond after 2 courses of induction therapy, and had poor tolerance of chemotherapy. And then the Cellworks TRI test recommended the 3-drug combination regimen of cladribine, trametinib and cytarabine as the optimal chemotherapy regimen. After 1 course of treatment, the patient achieved complete remission and minimal residual disease negative. After remission, the patient successfully underwent haplo-hematopoietic stem cell transplantation. She experienced a prolonged disease-free survival of 19 months and relapsed in November 2020, and passed away in April 2021. The overall survival time was 28.5 months.Conclusions:Cellworks TRI test based on CBM provides a new therapeutic approach for refractory AML patients, and its personalized treatment regimen based on genomics may improve the survival of patients.
RESUMEN
[Purpose] To find out the status and existing problems of graduate career planning education, and suggest some corresponding measures to up-grade the work of graduate career planning education of university of traditional Chinese medicine, and propose some improvements to enhance the com-prehensive ability and improve the quality of graduate students of TCM, and promote graduate employment.[Method] We view from the point of graduate career planning education, through the questionnaires and personal interviews to find out the status and existing problems of graduate career planning edu-cation. [Result]This study shows that, 76.87% graduate students of TCM have a more clear understanding for their personal abilities, 63.27% know what they want to engage in professional development trends, 76.56%know the importance of career planning affirming sexual attitudes,but only 35.12%express satisfaction to the graduate employment guidance,and each graduate's career expectations are not high.[ Conclusion] The university of traditional Chinese medicine should enhance graduate career planning education according to the actual school graduate, to establish a scientific and effective career planning e-ducation system to help students establish a correct concept of career employment, and promote and maintain sustainable development of personnel training mechanism TCM col eges.