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Chinese Journal of Applied Clinical Pediatrics
;
(24): 398-400, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-864013
RESUMEN
High mobility group box 1 is a kind of non-histone protein which expressed in the nucleus of eukaryotic cells.Which can promote inflammatory reaction and participate in the positive feedback loop of the production of cytokines after translocated outside the cells.As a result, it′s closely related to the pathogenesis of various autoimmune and inflammatory diseases.Recent studies have revealed that high mobility group box 1 may serve as a serum marker of Henoch-Sch?nlein purpura nephritis and lupus nephritis, and a predicator of the prognosis of juvenile idiopathic arthritis and intravenous immunoglobulin resistance in Kawasaki disease.