RESUMEN
This paper is accritical review as well as a comprehensive summarization of the research work done by the author and his team in the past few years. The important achievements they have obtained are. 1. the protective role of the complement system in experimental acute serum sickness has bsen identified, the participation of T lymphocytes to the pathology of immune complex diseases defined, and the cal-modulin mediation of immune complex inflammation clarified, and 2. several drugs including levamisole, cimetidine, goat-antirabbit thymocyte globulin, prostaglandin E2 and anisodamine were screened for their therapeutic efficiency on experimental acute serum sickness, which provides a clue for the further study on the treatment of immune complex diseases.