Research progress on role of macrophages in tumor immunotherapy / 中国免疫学杂志

Objective:Accumulating evidences prove that macrophages affect tumor initiation and prognosis. Especially,tumor-associated macrophages (TAMs) are considered to enhance tumor growth,progression,angiogenesis,invasion and metastasis. Furthermore,tumor suppressive microenvironment can " reeducate" and polarize the phenotype and function of TAM. Recently, researchers use different ways to interfere and modify the phenotype and function of macrophages,to improve the recognition, phagocytosis and antigen presentation of macrophage,and enhance its antitumor activity. We will discuss the pro-tumorigenic properties of macrophage and TAM-targeting therapy as a promising novel strategy for tumor immunotherapy.