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Objective To analyze the clinical effect of neoadjuvant chemotherapy( oxaliplatin combined with S-1) in the treatment of advanced gastric cancer,and to detect its influence on expressions of vascular endothelial growth factor(VEGF) and matrix metalloproteinase-2(MMP-2).Methods A total of 70 patients with advanced gastric cancer were randomly divided into research group ( n=35 ) and control group ( n=35 ) .The patients in the control group were given surgery treatment and general drug chemotherapy,while the patients in the research group were given the neoadjuvant chemotherapy on the basis of the control group.The incidence of cancer recurrence and the expressions of MMP-2,VEGF of the two groups were observed.Results In the research group,the expressions of MMP-2 or VEGF were significantly different before and after chemotherapy(χ2 =10.03,χ2 =9.11,all P<0.01). The 3-year survival rate in the research group(71.43%) was significantly higher than 45.71% in the control group,there was significant difference(χ2 =11.70,P<0.05).Conclusion Neoadjuvant chemotherapy can reduce the expressions of MMP-2 and VEGF in tumor tissues,indicates that it may play an important role in patients with advanced gastric cancer and can be used in clinic.
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Objective To investigate the risk factors of hyperamylasemia in patients with gastrointestinal minimally invasive surgery.Methods Two hundred and twenty cases with gastrointestinal were selected as our subjects who were hospitalized in General Surgery Department of the Center Hospital of Binzhou from Jan 2012 to Jan 2014.The patients were divided into normal group and hyperamylasemia group according to the postoperative serum amylase levels.The complications of two groups were recorded.The risk factors of hyperamylasemia were analyzed with univariate and Logistic multivariate.Results There were 98 cases (44.54％,98/220) of concurrent hyperamylasemia,45 cases (20.45 ％) of colon surgery,53 cases (24.09％) of stomach surgery.The complications of hyperamylasemia group and normal group were 28 cases (28.57％) and 8 cases (6.56％),and the difference was significant (x2 =4.869,P =0.006).Univariate analysis showed that there were significant differences in terms of the abdominal surgery,surgical approach,body mass index ＞ 25 kg/m2,operation time,position,CO2 insufflation pressure,pneumoperitoneum duration and pancreatic treatment between two groups(P ＜ 0.05).Logistic multivariate analysis showed that the abdominal surgery,CO2 insufflation pressure,pneumoperitoneum duration and operative time were independent risk factors with hyperamylasemia.Conclusion There is high incidence of hyperamylasemia after laparoscopic gastrointestinal surgery.Patients with pancreatitis and postoperative infection are easily to get hyperamylasemia complications.Upper abdominal surgery,CO2 insufflation pressure,pneumoperitoneum duration,operative time are independent risk factors for hyperamylasemia.