Facing fracture risk in patients with Parkinson′s disease:a Meta analysis / 重庆医学

Objective To evaluate whether the patients with Parkinson′s Disease (PD) having higher occurrence rate of frac-ture .Methods CMB ,CNKI ,PubMed ,Embase ,Web of Science ,Medline ,Embase and Cochrane Library were retrieved ,meanwhile which was assisted by the manual retrieval .The retrieval time was until February 2017 .The cohort studies on the occurrence rate of fracture in PD patients were collected .Then the included studies were analyzed after the data extraction and treatment evaluation . Results A total of 1160 articles were retrieved ,finally 11 cohort studies were included ,involving 988723 subjects .The analysis showed that the fracture occurrence risk in PD patients was significantly higher than that in the control group (RR=2 .09 ,95% CI:1 .91-2 .28) ,in which the occurrence rate of hip fracture was significantly higher than that in the control group (RR=2 .33 ,95%CI:1 .79-3 .02) ,while the occurrence rate of spinal fracture had no statistical difference (RR=1 .33 ,95% CI:0 .78-2 .27) ,and the fracture occurrence risk in male and female patients of PD group was significantly higher than that in the control group (RR=2 .40 , 1 .69 ,95% CI:2 .21-2 .60 ,1 .62-1 .76) .Conclusion The fracture occurrence risk in PD patients is significantly higher than that in the control group ,due to existence of certain geographic bias and publication bias risk ,it is needed more high quality clinical stud-ies to accurately evaluate whether the fracture risk in PD patients being much higher .

Effect of the Chinese Herbal Medicinal Ingredients in Huoxiang Zhengqi Liquid on Alcohol Metabolism in Rats / 法医学杂志

OBJECTIVES@#To study the changes of alcohol content and pharmacokinetic parameter in rats after taking Huoxiang Zhengqi liquid.@*METHODS@#The rats were randomly divided into three groups and given with white alcohol at the dose of 3.0 mL/kg, low-dose and high-dose Chinese medicine liquor, respectively. The blood was collected before administration and 5 min, 10 min, 15 min, 30 min, 1 h, 2 h, 3 h, 4 h, 5 h, 6 h and 8 h after administration by cutting rats' tails. The concentrations of alcohol in blood were detected by headspace-gas chromatography method. The main pharmacokinetic parameters were calculated by DAS 2.0, and then analyzed by SPSS 17.0.@*RESULTS@#The difference of maximum blood concentrations between high-dose Chinese medicine alcohol group and white alcohol group was statistically significant （P<0.05）. There was no significant difference in other pharmacokinetic parameters among three groups （P>0.05）.@*CONCLUSIONS@#The Chinese herbal medicinal ingredients in the Huoxiang Zhengqi liquid has no effect on the metabolism and elimination of ethanol in rats. The research provides useful reference for the qualitative assessment and processing of traffic accident cases involved in Huoxiang Zhengqi liquid and the studies related to drug-interaction.

The Clinical Nursing of 24 Patients with Acute Pulmonary Embolism Trdated with Thrombolytic and Anticoagulant Therapy / 昆明医科大学学报

Objective To investigate the related nursing measures of thrombolytic and anticoagulant therapy in acute pulmonary embolism,and to observe its effect.Methods Forty-eight patients with acute pulmonary embolism treated in the hospital in 2013 January-2014 year in July were enrolled in the study,and all patients were treated by thrombolytic and anticoagulant therapy,they were randomly divided into two groups with 24 cases in each group,the control group received routine nursing care,the observation group adopted psychological nursing before thrombolysis,oxygen and diet nursing care,medication nursing and the implementation of the puncture site nursing of thrombolytic therapy,the implementation of prevention of complications and nursing after thrombolysis,to compare curative effect.between two groups.Results The total effective rate of observation group was 20 cases (83.3％) and was significantly higher than the control group of 13 cases (54.2％),P＜0.05.The spirit,diet,sleep and mental status scores were (4.58 + 0.28),(4.35 + 0.43),(4.41 + 0.22),(4.47 + 0.22) in the observation group and were higher than in the control group,P＜0.05.The observation group ' anxiety level was significantly better than the control group,P＜0.05.Conclusion During thrombolytic and anticoagulant therapy for acute pulmonary embolism treatment,We should pay aftention to the nursing measures,standardize the implementation of psychological nursing and medication nursing has an important significance to alleviate the condition,so it has the important clinical value.

Diagnosis and evaluation of dural arteriovenous fistula with dual energy CT: a report of 6 cases / 中华神经医学杂志

Objective To explore the clinical application value of dual-energy imaging with dual-source CT in dural arteriovenous fistula (DAVF).Methods Six patients diagnosed as having DAVF by dual-energy angiography with dual-source CT (DECTA),conformed by DSA in our hospital from January 2009 to January 2013,were chosen in our study; their imaging data were retrospectively analyzed.Results The enlarged feeding arteries,dilated draining veins and dural venous sinus of the DAVF in all patients were clearly demonstrated on DECTA.The draining veins of all six patients routed into the intracranial vein with forming venous collaterals.The imaging results were concordant exactly with their results of DSA (100％).The other changes of DAVF by cranial CT were subarachnoid hemorrhage in 3 cases and brain hemorrhage in 2 cases.Conclusion DECTA can demonstrate distinctly the secondary changes,feeding arteries,draining veins,dural venous sinus,and the skull three dimensional structure of DAVF; the imaging results were concordant exactly with their results of DSA,and can replace it in a way,as a new non-traumatic screening choice for suspected DAVF patients before embolization therapy and surgical resection.

Initial clinical application results of dual energy CT angiography on head and cervical vessel diseases / 中华神经医学杂志

Objective To explore the clinical application value of dual-energy CT angiography (DECTA) for head and cervical vessel diseases. Methods The imaging data and diagnosis results of 146 patients suspected as having head and cervical vascular diseases and underwent DECTA in our hospital from February 2009 to August 2009 were analyzed, retrospectively and compared. Sixteen of them with positive results were also performed whole cerebral vessels DSA. Results Seventy-seven patients (52.74%) were found to have head and cervical vessel diseases under DECTA; 17 patients were diagnosed as having intracranial aneurysm, 13 with carotid artherosclerosis and stenosis, 13 with intracranial and vertebral artery stenosis, 9 with intracranial arteriovenous malformation (AVM), 7 with internal carotid artery (ICA) or vertebral artery occlusion, 4 with neck-face AVM, 3 with Moyamoya disease, 3 with intracranial tumors, 2 with cerebral infarction, 2 with intracranial phlebothrombosis, 1 without imaging in bilateral ICA, 1 with Sturg-Webber syndrome and 1 with primitive trigeminal artery.DSA results were concordant with the DECTA results by finding 15 of 16 patients (93.75%) with head and cervical vessel diseases; 8 patients were detected as having intracranial aneurysm, 4 with ICA or vertebral artery occlusion, 1 with carotid artherosclerosis and stegnosis, 1 with intracranial AVM and 1 with neck-face AVM. The one that DSA did not find any tumors was noted as having 2 microaneurysms by CTA. Conclusion The head and cervical vascular diseases and the feeding artery of tumor can be demonstrated distinctly with DECTA with high diagnosis accuracy and sensitivity.

Imaging of congenital coronary artery anomalies by dual-source computed tomography angiography / 中国医学科学院学报

<p><b>OBJECTIVE</b>To investigate the value of dual-source computed tomography (DSCT) angiography in the examination of congenital coronary artery anomalies.</p><p><b>METHODS</b>We retrospectively examined 2530 patients by DSCT angiography between January 2008 and September 2010. Congenital coronary artery anomalies were shown by maximum intensity projection, curved planar reconstruction, and volume rendering.</p><p><b>RESULTS</b>A total of 284 segments with congenital coronary artery anomalies in 225 patients were displayed. The anomalies included those originated from the main branch of coronary artery (n=121, including 35 segments of right coronary artery with high take-off origin and 24 segments of left coronary artery, 17 segments of right coronary artery dated from left aortic sinus, 4 segments of left coronary artery dated from right aortic sinus, 2 segments of left coronary artery dated from posterior aortic sinus, 2 segments of single coronary artery, and 37 segments of para-coronary artery) , coronary artery dysplasia (n=18) , coronary artery fistula (n=9, including 4 segments of right coronary artery-right ventricle fistula, 2 segments of right coronary artery-pulmonary artery fistula, 2 segments of left coronary artery-left ventricle fistula, and 1 segments of left coronary artery-pulmonary artery fistula) , and myocardial bridge (n=136) . In addition, 818 segments of left sinuatrial nodal artery original anomalies in 1720 patients whose sinuatrial nodal artery were well shown.</p><p><b>CONCLUSION</b>DSCT can be helpful in detecting the anomalies of coronary artery.</p>

Features of the dual energy technique with dual-source computed tomography for anterior cruciate ligament injuries / 中国医学科学院学报

<p><b>OBJECTIVE</b>To explore the diagnostic value of the dual-energy technique with dual-source computed tomography (DSCT) for anterior cruciate ligament injuries.</p><p><b>METHODS</b>The clinical data of 8 patients with arthroscopic results were retrospectively reviewed. All patients underwent two- and three-dimensional imaging by multiplanar reconstruction, volume rendering, and tendon mode on DSCT. Dual-energy characteristics were compared with arthroscopic results.</p><p><b>RESULTS</b>Six patients who were arthroscopically diagnosed as anterior cruciate ligament injuries, all of them were also correctly diagnosed by DSCT. Two patients who were arthroscopically diagnosed as normal, one was also diagnosed as normal by DSCT and the other was misdiagnosed. The overall agreement rate was 87.5% (7/8) . Under the dual energy tendon mode, the dual energy staining of the injured anterior cruciate ligament was lower than that of the contralateral normal cruciate ligament of the patient.</p><p><b>CONCLUSION</b>The staining diminution in DSCT imaging may be a new feature that can be used to effectively diagnose anterior cruciate ligament injury.</p>

Mental health state of parents of children with autism / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the mental health state of parents of children with autism.</p><p><b>METHODS</b>The mental health state was evaluated by conducting the Symptom Checklist (SCL-90) on parents of 34 children with autism and of 35 healthy children.</p><p><b>RESULTS</b>The SCL-90 total scores in the fathers (162.5±34.0) and mothers of autistic children (175.1±51.0) were significantly higher than those in healthy children's parents (142.4±42.8 and 152.3±40.6, respectively) (P<0.05). The SCL-90 scores of obsessive-compulsive symptoms, depression, anxiety and paranoia in the fathers of autistic children were significantly higher than those in the fathers of healthy children (P<0.05). The SCL-90 scores of obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, paranoia, psychotic symptoms, hostility and sleep/diet were significantly higher in the mothers of autistic children than those in the mothers of healthy children (P<0.05). The mothers of autistic children presented higher SCL-90 factor scores in interpersonal sensitivity, anxiety and psychotic symptoms than the fathers (P<0.05).</p><p><b>CONCLUSIONS</b>We should pay more attention to the mental health of parents of autistic children.</p>