Comfort analysis on ejection seat cushion based on sitting pressure / 医用生物力学

Objective To study the relationship between comfort and sitting pressure of ejection seat cushion. Methods By measuring sitting pressure distributions on seat cushions with different thickness, indices of sitting pressure such as the contact area, maximum sitting pressure and mean sitting pressure were discussed along with the subjective comfort scores to find the relationship between seat cushion comfort and indices of sitting pressure. Results The contact area, maximum sitting pressure and mean sitting pressure were significantly correlated with the subjective comfort scores. In addition, the comfort score did not increase when thickness of the seat cushion exceeded 4 cm. Conclusions The comfort of seat cushion could be well reflected and evaluated by the contact area, maximum sitting pressure and mean sitting pressure of seat cushion, and thickness of 4 cm is recommended for designing the seat cushion with material used in this paper.

RING Finger Proteins Are Involved in the Progression of Barrett Esophagus to Esophageal Adenocarcinoma: A Preliminary Study

BACKGROUND/AIMS: To investigate the differential expression of RING finger (RNF) proteins in Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). METHODS: The differential expression of RNFs in normal esophagus (NE), BE, and EAC was screened using microarray assay. Real-time quantitative polymerase chain reaction (PCR), tissue microarray assay, and Western blot analysis were independently performed to detect the mRNA and protein expression of screened RNFs. RESULTS: The expression of nine RNFs in the BE or EAC was 2-fold higher than those in NE. Among these proteins, the RNF32 and RNF121 expression in BE was 20.3-fold and 16.4-fold higher, respectively, than that in NE, and the expression of RNF24, RNF130, RNF141, RNF139, RNF11, RNF14, and RNF159 was upregulated more than 2-fold compared with NE. The expression of nine RNFs was not only upregulated in the EAC but was also positively related to the RNF expression in BE. The PCR results also indicated increased expression of these RNFs in BE and EAC compared to NE. Furthermore, the mRNA expression of all RNFs, except for RNF141 in EAC, was dramatically higher than those in the BE. Similar results were also obtained from the Western blot analysis. CONCLUSIONS: A total of nine RNFs play critical roles in the progression of BE to EAC.