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1.
Chinese Traditional and Herbal Drugs ; (24): 185-188, 2015.
Artículo en Chino | WPRIM | ID: wpr-854292

RESUMEN

Objective: To study the chemical constituents in the aerial parts of Tetracera asiatica. Methods: Silica gel, ODS, Sephadex LH-20 gel column chromatographies, and HPLC were used to isolate and purify the compounds. And the structures of the obtained compounds were identified by their physical properties and spectroscopic data. Results: Twelve compounds were separated and purified from the alcoholic extract of T. asiatica. They were identified to be rhamnocitrin (1), isorhamnetin (2), naringenin (3), rhamnetin (4), kaempferol (5), taxifolin (6), quercetin (7), tiliroside (8), quercetin-3-O-α-L-rhamnopyranoside (9), (-)-epicatechin 3-(3-O-methyl) gallate (10), epicatechin-3-O-gallate (11), and (-)-epicatechin (12). Conclusion: Compounds 1-12 are obtained from this plant for the first time.

2.
China Journal of Chinese Materia Medica ; (24): 458-462, 2015.
Artículo en Chino | WPRIM | ID: wpr-330254

RESUMEN

<p><b>OBJECTIVE</b>To study the alkaloids of Macleaya cordata and their anti-tumor activities.</p><p><b>METHOD</b>Alcohol and liquid-liquid extraction were used methods were used to extract the alkaloids constituents, and silica gel, reverse-phase octadecylsilyl (ODS), sephadex LH-20 chromatographic methods and HPLC were applied to isolate and purify compounds. MS, NMR spectroscopic methods were used to determine their structures. Furthermore, the cytotoxicity of these chemical components for MCF-7 and SF-268 cell lines was measured by MTT method.</p><p><b>RESULT</b>Twelve alkaloids were isolated from the fruits of M. cordata, and their structures were identified as: maclekarpine E (1), 6-acetonyldihyrochelerythrine (2), cavidilinine (3), 6-acetonyldihyrosanguinnarine (4), O-methylzanthoxyline (5), 6-methoxy-dihydrosanguinarine (6), spallidamine (7), 6-hydroxyldihydrochelerythrine (8), arnotianamida (9), dihydrosanguinarine (10), protopine (11), and cryptopine (12).</p><p><b>CONCLUSION</b>Compounds 1, 3, 7-9 were isolated from M. cordata for the first time, and compound 5 is a new natural product. The results of cytotoxic assay indicated that compound 6 showed strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μmol · L(-1) and 0.54 μmol · L(-1), respectively.</p>


Asunto(s)
Humanos , Alcaloides , Farmacología , Antineoplásicos Fitogénicos , Línea Celular Tumoral , Papaveraceae , Química
3.
China Journal of Chinese Materia Medica ; (24): 3301-3305, 2014.
Artículo en Chino | WPRIM | ID: wpr-244576

RESUMEN

The chemical constituents of 95% ethanol extract of Melastoma dodecandrum were isolated and purified by chromatography on silica gel, Sephadex LH-20, and HPLC, to obtain thirteen compounds eventually. On the basis of their physico-chemical properties and spectroscopic data, these compounds were identified as quercetin (1), quercetin-3-O-β-D-glucopyranoside (2), quercetin-3-O-(6"-O-p-coumaroyl) -β-D-glucopyranoside (3), kaempferol (4), kaempferol-3-O-β-D-glucopyranoside (5), kaempferol-3-O- [2",6"-di-O-(E)-coumaroyl]-β-D-glucopyra-noside (6), luteolin (7), luteolin-7-O-(6"-p-coumaroyl) -β-D-glucopyranoside (8), apigenin (9), apigenin-7-(6"-acetyl-glucopyranoside) (10) , naringenin (11), isovitexin (12), and epicatechin-[8,7-e] -4β-(4-hydroxyphenyl)-3,4-dyhydroxyl-2(3H)-pyranone (13). Eight compounds(3,5,6,8-11 and 13) were obtained from M. dodecandrum for the first time.


Asunto(s)
Apigenina , Cromatografía , Métodos , Cromatografía Líquida de Alta Presión , Dextranos , Flavanonas , Flavonoides , Química , Glicósidos , Química , Quempferoles , Luteolina , Magnoliopsida , Química , Plantas Medicinales , Química , Quercetina , Gel de Sílice
4.
China Journal of Chinese Materia Medica ; (24): 3304-3308, 2013.
Artículo en Chino | WPRIM | ID: wpr-238603

RESUMEN

To investigate the chemical constituents from Commelina communis, fifteen compounds were separated and purified by silica gel, Sephadex LH-20, and ODS column chromatography, and semi-preparative HPLC. By analyses of NMR and MS data as well as their physical and chemical properties, the structures of these compounds were identified as chrysoeriol-7-O-beta-D-glucoside( 1), methyl gallate(2), p-coumaric acid(3), protocatechuic acid(4), caffeic acid(5), p-hydroxybenzoic acid(6), 2-phenethyl-beta-D-gly-cosidase(7) , rhaponticin(8) , (7S, 8R) -dihydrodehydrodiconiferyl alcohol-9-O-beta-D-glucoside (9), isovitexin (10) , isofurcatain (11), isorhamnetin-3-O-beta-D-glucoside(12) , quercetin-3-O-alpha-L-rhamnoside (13) , isoquercitrin (14) , and 1, 2-dihydro-6, 8-dime-thoxy-7-1-(3, 5-dimethoxy-4-hydroxyphenyl) -N1, N2-bis-[2-( 4-hydroxyphenyl) ethyl] -2, 3-naphthalene dicarboxamide (15). Compounds 2, 5-9, 11, 13 were obtained from the genus Commelina for the first time.


Asunto(s)
Ácidos Cafeicos , Cromatografía Líquida de Alta Presión , Commelina , Química , Glucósidos , Hidroxibenzoatos , Quercetina
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