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Objective To study the relationship between serum fibronectin(Fn) and hyaluronic acid(HA) in patients with hepatocellular carcinoma(HCC) and their clinical value.Methods The serum Fn and HA levels in 50 cases of HCC 14 cases of benign hepatic disease and 100 healthy persons were determined by enzyme-labelled turbidimetry and radioimmuoassay.Results The serum Fn content (125.85?29.47)mg/L of the patients with HCC was significantly lower than those of both the benign hepatic disease(210.14?18.36)mg/L and healthy controls (219.96?26.26)mg/L,P
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Objective To explore the influence of preoperative chemotherapy (POCT) on telomerase activity(TA) of breast cancer and its mechanism. Methods TA was detected in 40 primary breast cancer specimens. Forty patients were divided into two groups: (1)POCT group. 32 patients, who underwent POCT using CMF scheme; (2) control group . 8 patients, who did not receive any POCT or radiotherapy. Results TA in POCT group(TA=0.499) was significantly lower than that in control group (TA=1.018). TA in patients received one , two or three times of POCT was 0.812,0.492 and 0.280 respectively. The difference of TA in patients received 1 time POCT and receive ≥ 2 times POCT was significant (P