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Abstract@#Campus exclusion behavior attracts much attention in the filed of school-based social exclusion research field. It threatens the normal relationship and belonging acquisition of primary and secondary school students, resulting in frustration of students needs and negative emotions and behaviors, inability to handle classmates and social relationships well, and hindering mental health development of. Evolution believes that behaviors have a certain adaptive value. From the perspective of evolutionary psychology, a preliminary interpretation of the influencing factors of exclusion in terms of language, needs and motivations, and social status has been made. Resource acquisition, hunting-gathering hypothesis, homosexual competition, etc. Provides a certain evolutionary basis. Therefore, in the intervention and prevention of rejection behaviors, creating a campus atmosphere that accepts diversity has a positive effect on the guidance of all students, and strengthening emotional and cognitive interventions also alleviates the adverse effects of rejection behaviors.
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Objective To explore the regulatory effect of miRNA on B-cell activating factor (BAFF) in chronic eosinophilic rhinosinusitis with nasal polyp (Eso CRSwNP).Methods Ten nasal mucosal samples were collected from Eso CRSwNP patients who were admitted and treated in our hospital between January 2012 and February 2013.Normal nasal mucosal tissues (n =10) served as control.The miRNA-targeting BAFF was predicted by bioinformatics tools.Immunohistochemistry and real time polymerase chain reaction (RT-PCR) were used to assess the protein expression of BAFF and the predicted miR-NA.The correlation between the predicted miRNA and BAFF was analyzed.Results Down-regulated expression of let-a was confirmed in Eos CRSwNP,while the BAFF protein expression was increased.Let-a was positively correlated with BAFF in nasal epithelia.Conclusions Let-a might contribute to mucosal eosinophilia in eosinophilic CRSwNP via targeting BAFF.