RESUMEN
Aquaporin-4 (AQP4) is an important structural basis for water regulation and trans- portation in the central nervous system,which participates in physiopathological processes, such as cerebrospinal fluid reabsorption, osmotic regulation, and cerebral edema formation. Protein kinase C (PKC) exists in various cells, it catalyzes the phosphorylation of serine or threonine residues on various protein substrates.In recent years, studies have found that there is a certain correlation between the expressions of AQP4 and PKC after ischemic stroke.This article re- views the distribution,function,functional regulation of AQP4 and PKC,and their relations in ischemia-reperfusion.
RESUMEN
Objective To investigate the clinical and magnetic resonance imaging (MRI) manifestations of acute disseminated encephalomyelitis (ADEM).Methods The clinical, neuroimaging and neuropathological data of a patient with ADEM were analyzed retrospectively.Results The clinical features of the patient included acute onset,paroxysmal dizziness, nausea and vomiting. Cerebral MRI showed multiple, asymmetrical, long T1 and long T2 signals, which appeared periventricular areas and white matter regions of frontal, parietal, occipital and temporal lobe. Pathologic examination showed brain tissue denaturalization with chronic inflammation and massive inflammatory lymphocyte infiltrations in perivascular spaces. Treatments such as surgery operation, dehydration and anti-infection were invalid, while glucocorticosteroid had stable therapeutic efficacy.Conclusions When a patient presents with dizziness, nausea and vomiting, and multifocal lesions appear in the white matter of brain in MRI, the diagnosis of ADEM must be taken into concern. Curative effect of glucocorticosteroid for this disease is confirmed.