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Objective:This study aimed to evaluate the diagnostic value of serum Golgi protein 73(GP73) alone and GP73 combined with liver stiffness measurement (LSM), aspartate aminotransferase/platelet ratio index (APRI), and 4-factor-based fibrosis index (FIB4) in diagnosing liver fibrosis in patients with chronic liver disease of different etiologies.Methods:A diagnostic test. A total of 68 patients who underwent liver biopsy in the Department of Traditional and Western Medical Hepatology of the Third Hospital of Hebei Medical University from October 2019 to December 2020 were selected to detect serum GP73 levels. iLivTouch was used to assess liver stiffness measurement (LSM). In addition, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), total bilirubin (TBil), direct bilirubin (DBil), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL) levels, and peripheral platelet (PLT) counts were assayed. The correlation between GP73 and the above indexes was assessed, and APRI and FIB-4 were calculated. SPSS 21.0 statistical software was used for statistical analysis. The area under the receiver operating characteristic curve was calculated to evaluate diagnostic efficacy of GP73 in identifying hepatic fibrosis stages. Furthermore, the difference between GP73 and liver stiffness, as well as APRI and FIB4 in diagnosing significant fibrosis was assessed.Results:Based on liver biopsy, 13, 18, 17, and 20 cases were diagnosed as stages S0-1, S2, S3, and S4, respectively. The AUC of GP73 diagnosing hepatic fibrosis stage S≥3 and S=4 were 0.806 and 0.844 at cut-off points of 2.06 and 3.27 μg/L, and the sensitivity and specificity were 93.5%, 61.5%, 90.0%, 70.3%, respectively. In addition, GP73 levels were positively correlated with the degree of liver fibrosis ( r=0.547, P<0.001). Conclusions:The efficacy of serum GP73 level in diagnosing the degree of liver fibrosis in patients with chronic liver disease from different causes was significantly higher than that of APRI, FIB4, and LSM. The combination of GP73 and FIB4 can further improve the accuracy of diagnosis of liver fibrosis staging S≥3 and S=4, which is a reliable serological marker for the diagnosis of fibrosis in patients with chronic liver disease.
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Objective:To assess the levels of self-compassion, psychological resilience, and academic adjustment of undergraduate students in a military medical university, and analyze their influencing factors and interactions.Methods:A total of 341 undergraduate students were selected by convenience and purposive sampling in a military medical university from April to May, 2022 for surveys with the General Information Questionnaire, the Chinese version of the Self-Compassion Scale, the Chinese version of the Connor-Davidson Resilience Scale, and the Academic Adjustment Scale for College Students. The collected data were analyzed through univariable analysis and multiple linear regression analysis to determine the influencing factors. AMOS 23.0 was used for path analysis.Results:The scores of self-compassion, psychological resilience, and academic adjustment of the students were at slightly high levels, with a significant positive correlation between one and another ( r s=0.580-0.611, all P<0.001). The influencing factors included professional identity, the level of received support, grade, time spent in student clubs, and the plan of postgraduate study (all P<0.05). The standardized direct effect of self-compassion on academic adjustment was 0.285 ( P=0.001), and the sum of the standardized mediating effects of psychological resilience and professional identity on self-compassion and academic adjustment was 0.314 ( P=0.001). The total mediating effect accounted for 52.42% of the total effect. Conclusions:The levels of self-compassion, psychological resilience, and academic adjustment of undergraduate students in the military medical university are influenced by multiple factors. Relevant departments should pay attention to specific populations and take targeted measures to increase the students' self-compassion, psychological resilience, and academic adjustment.
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Nonalcoholic steatohepatitis (NASH) has become the second leading cause of hepatitis and can further progress to liver fibrosis, liver cirrhosis, and even liver cancer; however, the detailed pathogenesis of NASH remains unclear, and there is still a lack of effective therapeutic drugs. MicroRNAs (miRNAs) are a class of non-coding, post-transcriptionally regulated, and highly conserved small RNAs in the body and play an important role in a variety of liver diseases. This article mainly reviews the role of miRNAs in the development and progression of NASH.