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Objective To explore the clinical efficacy and safety of recombinant human brain natriuretic peptide (rhBNP) in the treatment of acute heart failure(AHF) by observing the changes of hemodynamic parameters,cardiac function and inflammatory factors before and after treatment in the patients with AHF.Methods A total of 96 patients with AHF in our hospital from June 2012 to December 2015 were enrolled in this study and divided into the control group and observation group(n-48).The two groups were given the routine anti-heart failure treatment combined with sodium nitroprusside or rhBNP by intravenous dripping for 24 h.Fifteen cases were selected from each group for monitoring the hemodynamic change.The clinical effect was observed.The changes of heart rare,blood pressure,urine volume,cardiac function,plasma of NT-proBNP,IL-6 and hs-CRP before and after medication were observed.The occurrence of adverse reactions was also observed.Results The total effective rate of the observation group was significantly higher than that in the control group (P＜0.05).The PAP and PCWP at various time points after treatment in the observation group were significantly lower than those before treatment (P＜0.05).PAP and PCWP at various time points had statistical difference between two groups (P＜0.05).The levels of heart rate,systolic blood pressure,NT-proBNP,IL-6 and hsCRP levels after medication were significantly decreased in both groups,and the urine volume and LVEF were significantly increased (P＜0.05),and the difference between the two groups was statistically significant(P＜0.05).There was no statistically significant difference in the occurrence of adverse reactions between the two groups (P＞0.05).Conclusion The short-term efficacy of rhBNP in treating AHF is better than sodium nitroprusside,which can improve hemodynamics and cardiac function,reduces the level of inflammatory factors.
RESUMEN
Objective To explore the clinical efficacy and safety of recombinant human brain natriuretic peptide (rhBNP) in the treatment of acute heart failure(AHF) by observing the changes of hemodynamic parameters,cardiac function and inflammatory factors before and after treatment in the patients with AHF.Methods A total of 96 patients with AHF in our hospital from June 2012 to December 2015 were enrolled in this study and divided into the control group and observation group(n-48).The two groups were given the routine anti-heart failure treatment combined with sodium nitroprusside or rhBNP by intravenous dripping for 24 h.Fifteen cases were selected from each group for monitoring the hemodynamic change.The clinical effect was observed.The changes of heart rare,blood pressure,urine volume,cardiac function,plasma of NT-proBNP,IL-6 and hs-CRP before and after medication were observed.The occurrence of adverse reactions was also observed.Results The total effective rate of the observation group was significantly higher than that in the control group (P＜0.05).The PAP and PCWP at various time points after treatment in the observation group were significantly lower than those before treatment (P＜0.05).PAP and PCWP at various time points had statistical difference between two groups (P＜0.05).The levels of heart rate,systolic blood pressure,NT-proBNP,IL-6 and hsCRP levels after medication were significantly decreased in both groups,and the urine volume and LVEF were significantly increased (P＜0.05),and the difference between the two groups was statistically significant(P＜0.05).There was no statistically significant difference in the occurrence of adverse reactions between the two groups (P＞0.05).Conclusion The short-term efficacy of rhBNP in treating AHF is better than sodium nitroprusside,which can improve hemodynamics and cardiac function,reduces the level of inflammatory factors.
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Objective:To investigate the value of the three-dimensional CT reconstruction by computer photo process system for laryngeal carcinoma and control study with pathologic feature. Methods: Fifty patients with laryngeal carcinoma were scanned by helical CT which photos were three-dimensionally reconstructed with a photo processing system,and the images were compared with pathologic feature.Results:Clear three-dimensional photo of the laryngeal was obtained through the reconstruction of the helical CT.The images could be circular fully around the axis of X,Y and Z in order to find the best view of the diagnosis.Ninety-six percentage of the TNM stage of patients according to the images of three-dimensional reconstruction were consistent with the TNM stage after operation.The safe edge was obtained in 98% of the surgery for patients.Good correlations were showed in the images of the three-dimensional reconstruction of the larynx and pathologic specimens.Conclusion:Good consistent of the three-dimensional images of the larynx with pathologic specimen were useful for diagnosis,operation design and education.