Diagnostic value of baseline serum luteinizing hormone level for central precocious puberty in girls / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To evaluate the diagnostic value of baseline serum luteinizing hormone (LH) level for central precocious puberty (CPP) in girls.</p><p><b>METHODS</b>A total of 279 girls with precocious puberty were subjected to assessment of growth and development, bone age determination, baseline LH test, and follicle-stimulating hormone (FSH) test, gonadotropin-releasing hormone stimulation test, and other related examinations. Of the 279 patients, 175 were diagnosed with CPP and 104 with premature thelarche (PT). The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of baseline LH and FSH levels and their peak levels for CPP, and the correlation between the baseline LH level and the peak LH level was analyzed.</p><p><b>RESULTS</b>The CPP group had significantly higher bone age, baseline LH and FSH levels, peak LH and FSH levels, and ratio of peak LH level to peak FSH level than the PT group (P<0.01). The ROC curve proved that baseline LH level and peak LH level had good diagnostic values for CPP. Among the three bone age subgroups in the CPP group (7.0-9.0 years, 9.0-11.0 years, and >11.0 years), baseline LH level showed the best diagnostic value in the >11.0 years subgroup, with the largest area under the ROC curve. At a baseline LH level of 0.45 IU/L, the Youden index reached the peak value, and the sensitivity and specificity were 66.7% and 80% respectively, for the diagnosis of CPP. At a peak LH level of 9.935 IU/L, the Youden index reached the peak value, and the sensitivity and specificity were 74.8% and 100% respectively, for the diagnosis of CPP. The baseline LH level was positively correlated with the peak LH level (r=0.440, P<0.01).</p><p><b>CONCLUSIONS</b>Baseline LH level can be used as an primary screening index for the diagnosis of CPP. It has a certain diagnostic value for CPP at different bone ages, and may be used as a monitoring index during the treatment and follow-uP.</p>

Chemical compsition and pharmacological action of jojoba: Research advances / 国际药学研究杂志

Jojoba (the plant belonging to Simmondsiaceae) seeds are not only a kind of global special oil resources but also a type of good folk medicines because they are riched in jojoba oil and simmondsin and have many pharmacological effects such as anti-inflammatory effect, food inhibitor and promoting-antibiosis. The paper reviews the studies on jojoba chemical compositim,extraction and purification,detection and analysis methods, pharmacological activity and dosage development, in order to provide reference for further research and application.