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Objective@#MicroRNAs (miRNAs) are endogenous short stranded RNAs with a length of about 22 NT, which are highly conserved and have no coding function.Mature miRNAs play a role by specifically binding to the 3′untranslated region of the target gene, degrading the mRNA of the gene or hindering its translation at the post transcriptional level, so as to negatively regulate the expression of the target gene and play a biological role.In recent years, the research of miRNAs in cardiovascular diseases is increasingly in-depth.A large number of evidences show that miRNAs play a role in the pathogenesis of many cardiovascular diseases, and will become a potential marker and new treatment target for the diagnosis and prognosis evaluation of cardiovascular diseases.
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Objective:MicroRNAs (miRNAs) are endogenous short stranded RNAs with a length of about 22 NT, which are highly conserved and have no coding function.Mature miRNAs play a role by specifically binding to the 3′untranslated region of the target gene, degrading the mRNA of the gene or hindering its translation at the post transcriptional level, so as to negatively regulate the expression of the target gene and play a biological role.In recent years, the research of miRNAs in cardiovascular diseases is increasingly in-depth.A large number of evidences show that miRNAs play a role in the pathogenesis of many cardiovascular diseases, and will become a potential marker and new treatment target for the diagnosis and prognosis evaluation of cardiovascular diseases.
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Objective To study the influence of partial internal sphincterotomy on the postoperative pain after cutting seton treatment in patients with perianal infection. Methods A controlled study was carried out on 40 cases of cutting seton insertion with (Group A) or without (Group B) partial internal sphincterotomy. The subjects reported their postoperative pain at defecation and at rest respectively using a visual analogue scale (VAS). The intensity of pain between the two groups was compared. Results All the 40 patients were cured, without recurrence or fecal incontinence. During the period of cutting seton treatment, the pain scores at defecation and at rest were lower in the Group A than in the Group B ( P 0.05). Conclusions Internal sphincterotomy can significantly relieve anal pain after cutting seton treatment, being an effective method.