RESUMEN
Effects of melatonin ( MT) on Con A or LPS-induced prolifera-tive responses of splenocytes in mice and Con A induced interleukin 2 ( IL-2 ) production of splenocytes in rats were studied. The results showed that Con A and LPS induced proliferative responses of splenocytes were enhanced by in vitro treatment with MT (0.01~1?mol/L and 0.01~10?mol/L, reinduced-pectively ) . ConA IL-2 production of splenocytes were also enhanced by in vitro treatment with MT (1~10?mol/L), but MT has no effects oa above functions of splenocytes without activating by ConA or LPS. These data suggested that mitogen activated lymphocytes might be one of the target cells for MT.
RESUMEN
Effects of supernatants from cultured rat pineal glands on ConA and LPS induced proliferative responses of splenocytes in mice, ConA induced interleukin 2 (IL-2) production of splenocytes in rats were studied. These results showed that ConA and LPS induced proliferative responses of splenocytes were enhanced by supernatants from cultured rat pineal glands stimulated with 10 ?mol/L isoproterenol (ISO) for 60 min (Dilution. 1 : 45 ) , ConA induced IL-2 production of splenocytes in rats was also enhanced by the supernatants (Dilution: 1 : 135 ) .
RESUMEN
The protective effects of total glucosides of paeony (TGP) on eoperimental hepatitis were studied in mice. The elevation of SGPT and the decrese of serum protein and hepatic glycogen contents in D-Galactosamine or CCl4-induced hepatitis were significantly improved by pretreatment with TGP (10, 20mg ? kg-1d-1?7d,ip). It also remarkably diminished the hepato-cellular degeneration and necrosis induced by D-Galactosamine or CCI4.Moreover, ultrastructural studies showed that TGP markedly restored the structures of mitochondria, lysosome and endoplasma reticulum of hepatocvtes injured by D-Galactosamine. These results indicate that TGP has obviously protective effects on acute hepatitis. The mechanisms of its actions remain to be furthes studied.