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Objective:To analyze the relationship between cerebral blood flow diversion and prognosis of patients with acute large hemispheric infarction (LHI) caused by middle cerebral artery (MCA) M1 segment occlusion.Methods:From May 2015 to May 2018, 182 patients with acute LHI caused by MCA M1 segment occlusion in Ankang Central Hospital were selected. All patients underwent cranial Doppler examination at the early stage of admission. They were divided into flow diversion group (69 cases) and non-flow diversion group (113 cases) according to the condition of cerebral blood flow diversion. The hospital mortality, prognosis at 3, 6 and 12 months after onset in the two groups were analyzed statistically.Results:Compared with those in flow diversion group, the incidence of midline shift[41.6%(47/113) vs. 15.9%(11/69)], mechanical ventilation [32.7%(37/113) vs. 8.7%(6/69)], hospital death [26.5%(30/113) vs. 8.7%(6/69)] and adverse outcomes of 3 months [94.7%(107/113) vs. 66.7% (46/69)], 6 months [72.6%(82/113) vs. 46.4%(32/69)], 12 months [72.6%(82/113) vs. 43.5%(30/69)] after onset in non-flow diversion group were increased significantly ( P<0.05). Multivariate analysis indicated cerebral blood flow diversion was a risk factor for midline shift ( OR=28.721, 95% CI 1.933-35.807), mechanical ventilation ( OR=11.162, 95% CI 1.625-17.029), and poor outcomes at 3 months of onset ( OR=20.052, 95% CI 3.059-23.375), 6 months of onset ( OR=3.536, 95% CI 1.164-10.784) and 12 months of onset ( OR=4.412, 95% CI 1.398-13.971) ( P<0.05). Conclusions:The short-term and long-term prognosis of patients with acute LHI caused by MCA M1 segment occlusion can be predicted by the presence of cerebral blood flow diversion in transcranial Doppler examination of the early stage.
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Objective To label granulocytes in a state of differentiation in mouse bone marrow (BM) with EdU (5-ethynyl-2′-deoxyuridine) for further understanding the changes in granulocyte produc-tion at different stages of differentiation during inflammation. Methods C57BL/6 mice were intraperitoneal-ly (i.p.) injected with EdU and heat-inactivated Escherichia coli(HI E.coli). BM cells were harvested at different time points after HI E.coli injection and then stained with fluorescent-conjugated antibodies(Abs). Myeloblasts,promyelocytes,myelocytes, metamyelocytes and band and segmented neutrophils were identi-fied by fluorescence-activated cell sorting(FACS). The percentage of EdU-positive cells in each population was recorded. Results The percentage of EdU-positive myeloblasts in mice increased by 10.0% at 24 h af-ter intraperitoneal injection with HI E.coli,but decreased by 75.0% and 23.0% at 48 h and 72 h,respec-tively. The percentage of EdU-positive promyelocytes declined by 23.0%,54.5%,64.3% and 77.8% at 24 h,48 h,72 h and 96 h,respectively. The percentage of EdU-positive myelocytes increased by 60.0% and 10.0% at 24 h and 48 h,but decreased by 80.0% and 90.0% at 72 h and 96 h. The percentage of EdU-positive metamyelocytes increased by 50.0% at 24 h,but decreased by 33.3%,61.5% and 66.7% at 48 h,72 h and 96 h. The percentage of EdU-positive band and segmented cells increased by 14.0% at 24 h,but decreased by 50.0%, 77.8% and 88.0% at 48 h, 72 h and 96 h. Conclusion Emergency granulopoiesis occurred 24 h after the establishment of HI E.coli-induced model of acute peritonitis, which meant that the proliferation of myeloid precursor cells,especially that of myelocytes and metamyelocytes,was accelerated and resulted in increasing number of mature neutrophils immigrating to sites of inflammation.
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Objective To explore the application value of real-time shear wave elastography(SWE) in the liver injury caused by the blast injury.Methods The abdominal mild,moderate and severe blast injury animal models were built,liver and abdominal cavity conventional ultrasound scan and liver SWE measurement were processed before and immediately post-blast,and then the two groups' liver alanine aminotransferase (ALT) and the liver pathology results were compaired.Results The conventional ultrasound scan,immediately after the injury,had found no abnormities of the hepatic tissue in the mild blast injury group,while varying degrees of liver capsular rupture,part of the liver parenchyma regional uneven echo,subcapsular hematoma,obvious liver parenchyma interruption,effusion between the disruption of liver parenchyma and abdominal cavity effusion etc.a series of liver injury had been found in the moderate and severe groups,and the severe blast injury group was more obvious.Three groups' immediately liver elasticity and ALT of post-blast liver injury were increased compared with the pre-blast,the liver elasticity and ALT of each group pre-and post-blast comparing had statistically signifcant (P ＜0.05),and the three groups post-blast immediately liver elasticity and ALT and any two groups' comparing also had statistically significant (P ＜0.05).Conclusions After the blast injury,the changes of liver elasticity were associated with the liver injury degree,the higher elasticity values suggest the heavier damage.Based on conventional ultrasonography,SWE could provide a new evaluation method for the judgement of liver balst injury,especially in the diagnosis of mild liver blast injury.
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Disabled-2 [Dab2] is an important endocytic adaptor which plays an inhibition role in cancer cell growth. The objective of this study was to systematically review expressions of Dab2 in human cancers. Eligible studies about Dab2 in human cancers were retrieved from databases of PubMed, Embase, Web of Science. Odds Ratios [ORs] with 95% confidence intervals [CIs] were calculated using Review Manager 5.0 software and statistical analyses were performed by the SPSS 13.0 software. Fourteen case-control studies with a total of 689 human tumor tissues, 332 control tissues and 32 cancer cell lines were included in the meta-analysis study. The results indicated loss expressions of Dab2 were observed in 74.9% and 46.9% in human malignant cancer tissues and cancer cell lines, respectively. The ratio of Dab2 promotor hypermethylation is 34.54% in cancer tissues which Dab2 expression are lost, but none in the control tissues or cells by Methylation-specific PCR [MSP]. The expressions of Dab2 are frequently lost in human malignant cancer tissues, and promotor hypermethylation of Dab2 are common in human malignant cancer tissues, which is an important factor for the loss expression of Dab2 in human cancers tissues
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The human Dab2 gene has a variety of physiological functions,and plays important roles in various signal transduction pathways.Researches have shown that reduced expression of Dab2 was closely related to the occurrence and development in many malignant cancers,and Dab2 has been regarded as a tumor suppressor.This paper reviewed about multiple researches on the structure and functions of Dab2,and explored the specific mechanisms in oncogenesis.
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Objective To explore the method and management of pre-hospital care and raise the level of traffic injuries in pre-hospital care by summarizing the clinical features of death patients with severe tragic accident trauma Methods The basic data of 62 death patients with severe traffic accident trauma was analyzed according to death report statistics of severe traffic accident trauma from January 1st,2005 to December 31th,2008 Results Brain injury death accounted for most of traffic accident trauma death.The mortality rate of brain injury in the wounded wag 8.28%(13/157),but of asphyxia and hemorrhagic shock was 2.55%(4/157),3.18%(5/157)respectively in 2005.With the development of treatment and rescued in time, the mortality rate reduced to 6.11%(11/180),0,0.56%(1/180)in 2008.Conclesions It should be trying to shorten the time of pre-hospital care for pafients with trsffic accident trauma,especially in patients combined with hemorrhagic shock,asphyxia,severe brain injury.It is concluded that rapid and effective pre-hospital care can significantly reduce death rate and self-help or each other rescue training would also be effective to reduce mortality.