RESUMEN
Objective:To investigate the relationship between the expression of EZH2 and the prognosis of elderly patients with rectal cancer and the mechanism of EZH2 in the progression of rectal cancer.Methods:36 cases of elderly patients with rectal cancer who underwent surgery in our hospital from January to June 2010 were included in this study.The expression of EZH2 in colorectal cancer tissues and adjacent tissues was analyzed and the differences were analyzed.All the patients were divided into positive and negative groups according to the expression level of EZH2.The correlation factors and risk factors of EZH2 expression were analyzed.All patients were followed up for 1 year to assess the quality of life of patients with prognosis and to analyze the correlation with the expression of EZH2;5-year follow-up of patients in both groups compared to 5-year progression-free survival rate of progression-free survival And overall survival(PFS) and overall survival (OS) survival curves were recorded.Results:The positive rate of EZH2 was 69.44％ in CRC and 38.89％ in cancerous tissues,and the positive rate of EZH2 in cancer tissues was significantly higher than that in adjacent tissues (P＜0.01).Age,pathologic type,The positive rate of EZH2 expression in lymph node metastasis group was significantly higher than that in lymph node metastasis group (P＜0.05).Logistic regression analysis showed that EZH2 expression was an independent risk factor of CRC lymph node metastasis.The QLQ-30 quality of life score was significantly higher in EZH2 low-expression group than that in EZH2 high-expression group (P＜0.01).The expression level of EZH2 was negatively correlated with QLQ-30 quality of life score (r=-0.573,P＜0.01).The 5-year progression-free survival rate of the 5-year EZH2 low-expression group was 86.67％ and the 5-year overall survival rate was 93.33％.The 5-year progression-free survival rate was 52.38％ 61.90％.The 5-year progression-free survival rate and 5-year overall survival rate of EZH2 low expression group were significantly higher than those of EZH2 high expression group (P＜0.05).Conclusion:The high expression of EZH2 is closely related to the progression of rectal cancer.It can be used as an important predictor of prognosis quality of life,progression-free survival time and overall survival time.
RESUMEN
Objective:To study the expression of tumor suppressor factors SEMA3F,CYLD and miR-454 in rectal cancer.Methods:21 patients with colorectal cancer admitted in our hospital from January to March in 2016 were selected as the study materials.The tumor inhibitoryfactor SEMA3F in rectal cancer tissue,cancerous surrounding tissue and normal rectum tissue were detected respectively,CYLD and miR-454,and to analyze the correlation between tumor suppressor factors SEMA3F,CYLD and miR-454,and to explore their roles in the carcinogenesis and progression of rectal cancer.Results:The expression of SEMA3F,CYLD and miR-454 in cancer tissue,paracancer tissue and normal tissue were statistically significant (P＜0.01).The levels of SEMA3F and CYLD were significantly lower in patients with metastasis than those without metastasis,and miR-454 was significantly higher than that in patients without metastasis (P＜0.01).The expression level of SEMA3F and CYLD in CRC tissues was significantly higher than that in moderately and poorly differentiated tissues,and the expression of miR-454 was significantly lower than that in moderately and poorly differentiated ones (P＜0.01).There was significant negative correlation between tumor suppressor CYLD and miR-454 (r=-0.971,P＜0.01).There was a significant negative correlation between tumor inhibitory factor SEMA3F and miR-454(r=-0.955,P＜0.01).Conclusion:The tumor suppressor factors SEMA3F and CYLD play an important role in inhibiting the formation and proliferation of cancer cells in colorectal cancer.The expression of tumor suppressor factors SEMA3F and CYLD in colorectal cancer is high in the early stage and gradually declines with the progression of the disease.MiR-454 can promote the growth of rectal cancer cells The expression of tumor suppressor factors SEMA3F,CYLD and miR-454 in colorectal carcinoma were significantly higher than those in SEMA3F and CYLD.The expression of tumor suppressor factors such as SEMA3F,CYLD and miR-454 were significantly correlated with the progression and prognosis of rectal cancer The evaluation has important reference value.