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With the development of medical research, the treatment of diabetes has not only limited to the internal medicine medications, surgery has become a new treatment. International Dibetes Federation officially recommended that metabolic surgery can be used for the treatment of obesity combined type 2 diabetes in 2011.
RESUMEN
AIM: To investigate p16 gene alterations in gastric carcinoma. METHODS: 36 fresh tumor specimens taken from gastric cancer patients were analyzed for p16 gene deletion and mutation by polymerase chain reaction (PCR) and DNA sequencing. RESULTS: Homozygous deletion of exon 1 and exon 3 was observed in 2 cases and 3 cases of diffuse carcinoma, respectively. The frequency of homozygous deletion was 13.89%. No p16 gene point mutation was detected. CONCLUSION: The deletion of p16 genes may be related to gastric carcinogenesis.