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This paper describes the development and validation of a liquid chromatography-mass spectrometric assay for propafenone and its application to a pharmacokinetic study of propafenone administered as a new propafenone hydrochloride sustained-release capsule (SR-test), as an instant-release tablet (IR-reference) and as the market leader sustained-release capsule (Rythmol, SR-reference) in male beagle dogs (n=8). In Study A comparing SR-test with IR-reference in a crossover design T max and t 1/2 of propafenone for SR-test were significantly higher than those for IR-reference while C max and AUC were lower demonstrating the sustained release properties of the new formulation. In Study B comparing SR-test with SR-reference the observed C max and AUC of propafenone for SR-test (124.5±140.0 ng/mL and 612.0±699.2 ng·h/mL, respectively) were higher than for SR-reference (78.52±72.92 ng/mL and 423.6±431.6 ng·h/mL, respectively) although the differences were not significant. Overall, the new formulation has as good if not better sustained release characteristics to the market leader formulation.
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Tort Liability Law set tougher requirements on the validity and authenticity of medical records,featuring explicit protection of patient rights of informed consent.Based on the changes in the law since its enforcement,the authors studied existing deficiencies of electronic medical records and came up with the following suggestions.Establish sound legal accreditation system for electronic medical records; perfect related laws and regulations to ensure standard application of the electronic medical records; and work out regulations to make medical staff aware of their legal responsibilities when applying electronic medical records.These recommendations will enable electronic medical records better fit the current legal environment onto the track of healthier development.
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The aim of this study was to assess the association between insulin resistance, metabolic syndrome and nonalcoholic fatty liver disease [NAFLD] in Chinese adults. Fifty five subjects with NAFLD and 55 controls were enrolled for the study. Waist circumference, blood pressure, plasma triglyceride, high density lipoprotein cholesterol and fasting plasma glucose concentrations and homeostasis model assessment of insulin resistance [HOMA-IR] values as an index used to quantify insulin resistance were measured and analyzed. Logistic regression was analyzed to predict independent risk factors of NAFLD. The prevalence of metabolic syndrome in NAFLD group was obviously higher than in controls group [47.3% VS 3.6%, P<0.001]. There were all significant differences of each component of metabolic syndrome and HOMA-IR values in comparison of nonalcoholic fatty liver disease [NAFLD] and controls group. In a logistic regression analysis, age, diastolic blood pressure, waist circumference and HOMA-IR were the covariates independently associated with the presence of NAFLD [Odds Ratio-1.107, 1.083, 1.218 and 16.836; 95% CI: 1.011 1.211, 1.001-1.173, 1.083 1.370 and 3.626-78.168, respectively; P<0.05]. NAFLD was closely associated with metabolic syndrome and insulin resistance was a very strong predictor of NAFLD
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Humanos , Masculino , Femenino , Síndrome Metabólico , Hígado Graso , Adulto , Circunferencia de la Cintura , Presión Sanguínea , Triglicéridos , HDL-Colesterol , GlucemiaRESUMEN
Through analyzing the doctor-patient relationship from these three aspects,such as its attributes,legislation in current situation as well as the relationship between morality and law,this article deems the way for dealing with doctor-patient should be focused on the combination of morality and law.Furthermore,it brings forward that we should also strengthen medical education,standardize medical staff's working qualification and perfect the system which deals with doctor-patient relationship to establish civil and hamonious relationship between doctors and patients.