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Rev. Inst. Med. Trop. Säo Paulo ; 34(2): 137-140, Mar.-Apr. 1992.
Artículo en Inglés | LILACS | ID: lil-320621

RESUMEN

The authors developed a comparative study of the various methods of assessment of immune response to Hepatitis B vaccine. Eighty-six health care professionals underwent a vaccination programme with three doses of plasma-derived vaccine against Hepatitis B (H-B-Vax, Merck, Sharp & Dohme) given intramuscularly. Assessment of immune response was carried out three months after the end of the programme, by radioimmunoassay (RIA) and enzyme immunoassay (EIA). The results showed that the semi-quantitative assessment of Anti-HBs antibodies by RIA or EIA was perfectly comparable to the reference method (quantitative determination of antibodies by RIA). In view of these findings, the authors suggest a standardization of assessment of immune response to the vaccine, thus permitting correct planning of booster doses and easier comparison between different studies.


Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Persona de Mediana Edad , Anticuerpos contra la Hepatitis B , Vacunas contra Hepatitis B , Antígenos de Histocompatibilidad Clase II/inmunología , Anticuerpos contra la Hepatitis B , Vacunas contra Hepatitis B , Técnicas para Inmunoenzimas , Radioinmunoensayo , Factores de Tiempo
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