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Objective: To investigate whether Shuxuening injection has a protective effect on myocardial injury in rats with cecal ligation and puncture(CLP)- induced sepsis. Methods: Thirty SD rats were randomly allocated to Sham group, CLP group and Shuxuening group (SXN group). In the Shuxuening group, Shuxuening injection was intraperitoneally injected at a dose of 1 mg(0.3 ml)/body weight 1 h before CLP challenge. The sham and CLP groups received an equal volume of saline injection (0.3 ml/kg) at the same time points. Six hours later, the blood samples were obtained from abdominal aorta to determine the contents of TnT, TNF-α, and IL-1β. Meanwhile, MDA contents and SOD activities in myocardial tissues were also tested and the pathologic changes of the myocardial tissue were observed by H-E staining. Results: Compared with CLP group, the serum contents of TnT, TNF-α, and IL-1β and myocardial tissue MDA were decreased in Shuxuening group; and the myocardial tissue SOD activities were significantly increased in Shuxuening group (P<0.05 or 0.01). Microscope observation showed that the degrees of myocardial congestion, edema, and inflammatory cell infiltration were greatly improved in the Shuxuening group compared with in the CLP group. Conclusion: Our results suggest that Shuxuening can protect against CLP-induced myocardial injury in rats, probably through scavenging free radical and inhibiting release of inflammatory mediators.
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Objective To compare the efficacy of alfentanil and remifentanil in minimizing the propofol injection pain. Methods A total of 175 adult female patients undergoing gynecological procedures with general anesthesia were randomly divided into four groups.Patients received alfentanil 1mg(2 mL,AL group,n=43),remifentanil 0.01 mg(2 mL,REM1 group,n=43),remifentanil 0.02 mg(2 mL,REM2 group,n=45) or normal saline(2 mL,control group,n=44) 30 seconds prior to propofol administration.Visual analogue scale(VAS) was employed to evaluate the subjective feelings of pain due to propofol injection,and adverse effects were recorded. Results One patient in REM2 group and one patient in control group were excluded due to difficulty in venous catheterization.The injection pain in AL group,REM1 group and REM2 group was significantly less severe than that in control group(P