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Aim To study the effect of resveratrol on proliferation of liver cancer SMMC-7721 cells and the relevant mechanism.Methods SMMC-7721 cells were treated with different concentrations of resveratrol.Cell proliferation was tested by cell proliferation assay and colony-forming experiment.The effect of resveratrol on cell cycle of SMMC-7721 cells was detected by flow cytometry.The activation of mTOR/p-mTOR proteins was detected by Western blot.Results Compared with control group, resveratrol inhibited SMMC-7721 cell proliferation in a dose-dependent manner(P<0.01);cell cycle detection showed that SMMC-7721 cells were arrested at G0/G1 phase by resveratrol;Westren blot assay showed that resveratrol down-regulated p-mTOR expression.Conslusion Resveratrol inhibits human SMMC-7721 cell proliferation and arrests the cell cycle at G0/G1 phase, while the inhibition mechanism may be related to activation of mTOR signaling pathway by resveratrol.
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Objective: To explore the effect of valsartan on inflammatory cytokines in patients with hypertension combining paroxysmal atrial ifbrillation (PAF). Methods:A total of 60 patients with hypertension combining PAF converted to sinus rhythm were studied and the patients were divided into 2 groups. Control group, the patients received felodipine and Valsartan group. n=30 in each group, all patients were treated for 6 months. In addition, there was a Normal group including 30 healthy subjects. The levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and left atrial diastolic diameter (LADd), the sinus rhythm maintenance rate were examined and compared before and after treatment among different groups. Results: Compared with Normal group, the levels of hs-CRP, IL-6 and LADd were obviously higher in patients at both Control group and Valsartan group, all P Conclusion: Valsartan may inhibit inflammatory response and improve atrial structure remodeling, therefore better maintain the converted sinus rhythm in patients with hypertension combining PAF. The anti-inlfammatory effect of valsartan might be independent from its anti-hypertension effect.
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ay of the anatomical features of the SN and clinical diagnosis of diseases related to the nerve.
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[Objective] To design anatomical steel plate for internal fixation of scapular neck fracmre.[Method]By observing the scapular structure and scapular fracture type,imaging a form of anatomical steel plate for internal fixation of scapular neck fracture,the needed relative measurement datum of scapula were obtained.Forty pairs of scapular spechnens of men and women were measured,relative datum were obtained.Based on the measurement,scapular neck fracture plate was designed.The steel plates were applied in patients with scapular neck fracture or scapular body fracture,patients were followed up after operations,the results were observed.[Result]Seven patients with scapular neck fracture or scapular body fracture were operated with the anatomical steel plates,the steel plates were obedient to the scapulas greatly,the fixations were strong,the operations were easy,the time of operations were short,seven patients were followed up for 12-18 months showing satisfactory results.[Conclusion]The design of anatomical scapular neck fracture steel plates is satisfactory,when using tile plate to fix scapular neck fracture.The fixation is strong,using the steel plate can be benificial to patient's early exercise.It has advantages of preventing complications,promoting fracture to heal,making the scapular operation easy,shortening the time of operation,lessening the blood in operation.This type of anatomical steel plate has the value to be popularized.
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Objective To discuss the problems of using high pressure injector in the 16-detector-row CT. Methods Reviewed and analyzed the courses of using high pressure injector in the 16-detector-row CT for 799 patients. Results 774 patients obtained successful infusion,contrast medium hydrops were occurred in 20 patients,2 patients were infusion failure and 3 patients were redid for misoperation. Conclusion Master the details of operating high pressure injector can alleviate the pain of patients,and then obtain the satisfactory effect.
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Objective To discuss the value of 16-slice spiral CT urography in clinical diagnosis.Methods To compare the images between CR excretory urography,CT and MPR,which are the results of 26 cases who were examined by both CR and 16-slice spiral CT urography.Results From the comparison,it is found that the spiral CT urography images are better than that of the CR excertory urography,and at the same time,the relationship between the parenchyma of the renal,renal pelvis,ureter,bladder and the urinary organs and adjacent structures can be demonstrated clearly.Conclusion The scanning time of the spiral CT is shorter.The machine can not only reconstruct powerfully but also work out better images,and the result is better than CR excretory urography which can not detect some details in its images.Therefore CR excretory urogaphy can be replaced by 16-slice spiral CT urography regardless of its cost.
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Objective:To study the prevention methods of radiation caries for the patients with nasopharyngeal carcinoma receiving radiotherapy. Methods:Seventy-five patients with nasopharyngeal carcinoma received dental check and treatment before radiotherapy. They also received the instructions on preventive oral hygiene. After radiotherapy, the patients were followed up.Results:Fifty patients were followed up for 1-3 years. Radiation caries was observed in 4 cases with poor oral hygiene habit. Conclusion:A comprehensive regime of dental care can prevent radiation caries effectively.
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Objective To evaluate the relationship between the CT features and pathology of peripheral adenocarcinoma.Methods Eighty patients with peripheral pulmonary adenocarcinoma (including 44 well-differentiated,23 moderate and 13 poorly one)confirmed by pathology were collected in this series.The comparative study on CT finding and pathologic data was done.Results Air bronchograms were seen in 35 cases (79.6%)in high differential adenocarcinoma and were seen in 7 cases(30.4%) in moderate differential adenocinoma but not seen in low differential ones.The emergeua rate of lobular sign,burr sign,sign of hollowed and sign of blood vessel bundle was high in low differentiated adenocarcinoma.Lymphnode metastases and distant matestasis in moderate-low differentiated adenocarcinoma were much more than that of high differentiated ones. Conclusion The air bronchogram in nodule on CT image is important in evaluating diagnosis and progrosis of peripheral adenocarcinoma.
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Epidemic investigation was made in 2080 diabetic cases in Henan Province. Results showed that TCM Xiaoke syndrome is not only related to the pathological changes of the Lung in Upper - jiao, Spleen -stomachin middle - jiao and kidney in lower - jiao, but also closely related to pathological changes of the liver. During the early stage when mild hyperglycemia is present, the manifestations of deficient liver ( of liver blood and liver Yin) are especially conspicuous with a frequency of occurrence only less than Qi -deficiency syndrome. This important new discovery reminds us that " liver" is not to be overlooked clinically. It also proves that application of nourishing, softening, converging, and soothing the liver are reasonable and scientific methods for diabetes treatment.