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Journal of Biomedical Engineering ; (6): 401-404, 2011.
Artículo en Chino | WPRIM | ID: wpr-306551

RESUMEN

The delivery of bioactive macromolecular substances into cells provides an efficient approach to changing cellular conditions, and is thus of enormously potential therapeutic significance. It has also been an extremely difficult approach due the the impediment and protective nature of cell membrance until the protein transduction domain's (PTD's) capability to ferry macromolecule across cell membrance was discovered. PTD's efficient transductive function has rendered an exciting promise to the clinical treatment of diseases, therapeutic proteins drug development, and basic medical and applied research. The technology has been successfully applied to deliver a variety of substances into cells or tissue organs, and its superior application values have been explicitly demonstrated.


Asunto(s)
Humanos , Permeabilidad de la Membrana Celular , Fisiología , Sistemas de Liberación de Medicamentos , Métodos , Terapia Genética , Señales de Clasificación de Proteína , Transporte de Proteínas , Fisiología
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