RESUMEN
Sustained release tablets are pharmaceutical dosage form comprising a wide range of pharmaceutical products. Metformin HCL is an oral hypoglycemic agent which is prescribed as drug of choice of biguanide class. Many trials were made to formulate this drug in a sustained release dosage form. by employing dispersion [fusion method] with various retardants [Beeswax, Carnauba wax stearic acid] and the channeling agent polyethylene glycol [PEG]. It was found that the most satisfactory tablets could be obtained by incorporating a mixture of carnauba wax stearic acid and PEG 4000 as coated material. Also faster release was obtained when smaller coated granules were used. On the other hand, a comparative study of the physical properties of the prepared formula and glucophage. Retard [R] tablets showed that both products were more or less similar