Apoptosis in rat corpus cavernous penis after neruotomy of bilateral dorsal nerve of penis and/or cavernous nerve / 法医学杂志

OBJECTIVE@#To observe the apoptosis in penile corpus cavernous after neurotomy.@*METHODS@#After neurotomy, 78 SD rats were randomly assigned to experimental and normal control groups at day 1, 2, 4, 8, 16, and 32 time point. The quality was measured by DNA Ladder and the quantitation was measured by TUNEL. The location of apoptosis was detected by dual stained with immunohistochemistry and TUNEL.@*RESULTS@#After transaction of cavernous nerve, dorsal never, and both nerves, the apoptosis in experimental and control group showed a statistically significant difference (P<0.0046); however there was no statistically significant difference after bilateral dorsal nerve transaction alone (P>0.0046). There was a statistically significant difference in apoptosis between cavernous smooth muscle cell and endothelial cell groups (P<0.05).@*CONCLUSION@#Cavernous nerve transection induces apoptosis in smooth muscle cells of the rat penis, but nor does dorsal nerve transaction alone. There is no statistically significant difference in apoptosis between cavernous nerve injury alone and combination injuries of cavernous nerve and dorsal nerve.

Peripheral nerve injury and male sexual dysfunction / 法医学杂志

The genital organ is innervated by autonomic and somatic nerve. The former is both sympathetic and parasympathetic nerve and the later is comprised by sensory and motor fibers. The symptoms of male sexual dysfunction are sexopathy, erectile dysfunction, disorder of ejaculation and orgasm, and pianism. Not only different symptom but the same symptom can be induced by different injured nerve. The relationship between peripheral nerve injury and male sexual dysfunction should be understood correctly.