RESUMEN
The circadian rhythm regulates many physiological processes of the human body. The circadian rhythm sleep-wake disorder refers to a type of disease caused by the mismatch of sleep-wake cycle and circadian rhythm. It affects the human body's cognitive function and metabolic processes. The circadian rhythm sleep-wake disorder also promotes the growth of malignant tumors, directly and indirectly, by changing the expression of clock genes and inhibiting the secretion of melatonin. This article discusses circadian rhythm sleep-wake disorders; the subgroups it includes, the pathological state it causes, and the relationship between it and the development of malignant tumor. We hope to provide possible treatment measures for tumors affected by circadian sleep-wake disorders.
RESUMEN
Rapid eye movement sleep behavior disorder (RBD) is characterized by dream enactment and rapid eye movement (REM) sleep without atonia. RBD is closely related to α-synucleinopathy disease, including Parkinson's disease (PD), Lewy body dementia (DLB) and multiple system atrophy (MSA). Many studies have discussed the markers, heredity, cognition, autonomic nervous function of RBD, and the predictive value for neurodegenerative diseases. This article reviews the research progress of early markers and treatments in recent years, and discusses future research directions.
RESUMEN
Herpesviruses is one of the most common human infectious diseases, which can be divided into different types based on clinical infection degree.Herpes simplex virus usually results in buccal and genital mucocutaneous infections, while cytomegalovirus is the most common opportunistic pathogen associated with significant morbidity and mortality in immunocompromised hosts, especially in transplant and cancer patients.Although nucleoside analogues are effective antiviral drugs, the emergence of drug-resistant viruses has created a barrier for the treatment of herpesviruses infections, especially in immunocompromised patients.Therefore, novel therapeutic agents are needed to avoid the limitations of drug resistance.In this article, research progress in the therapeutic agents for drug-resistant herpesviruses was reviewed from the aspects of non-nucleoside analogues, novel antiviral targets and newly antiviral mechanisms.