Increasing prevalence of antimicrobial resistance among organisms isolated from blood culture in a Singapore hospital.

The blood culture isolates obtained over the period 1985-1990 in a general teaching hospital were reviewed to determine trends in the prevalence of resistance to antimicrobial drugs. The percentages of Staphylococcus aureus isolates resistant to methicillin increased each year. Resistance among coagulase negative staphylococci also increased in prevalence: by 1990 approximately 50% of such isolates were resistant to methicillin, erythromycin, co-trimoxazole and gentamicin, 24% were resistant to clindamycin, 20% to fucidic acid but only 0.5% to vancomycin. Isolates of Enterobacteriaceae, excluding community-acquired salmonellae, showed increasing prevalence of resistance to beta-lactams, as did Acinetobacter spp isolates to gentamicin, co-trimoxazole and ceftriaxone. The isolates of Pseudomonas aeruginosa were exceptional, having no evident increase in the prevalence of resistance during the period. The rapid increases observed in relation to the other pathogens indicate the need for an antibiotic policy based on continuous surveillance of susceptibility patterns in the hospital.

Histochemical study on the behavior of glycogen and total lipids in pregnant albino rats and their progenies treated with naphazoline

The histochemical study of 25 pregnant rats liver submitted to nasal drop instillation of saline and naphazoline at increasing concentrations, at the 19th day pregnancy, showed glycogen decrease and total lipid increase, only at a concentration of 1:1,000 of naphazoline. In this group occured also an increase of fetal liver lipids.

Comportamento da glicose, dos lipideos totais e da fosfatase acida no plasma de ratas prenhes, tratadas com diferentes doses de adrenalina, administrada sob a forma de gotas nasais. / The behavior of glucose, total lipids and acid phosphatase in the serum of pregnant rats treated with different dofes of adrenaline, administered under the formula of nasal drops

Vinte e cinco ratas prenhes, divididas em cinco grupos, foram tratadas durante todo o 19o. dia de gestacao, com instilacao de gotas nasais de 4 em 4 horas; o primeiro grupo considerado controle recebeu soro fisiologico e os restantes concentracoes crescentes de adrenalina. Apos 24 horas de tratamento, observou-se alteracao dos niveis de lipemia e de fosfatase acida no plasma, apenas quando foi empregado adrenalina em super dosagens, enquanto os niveis de glicemia mantiveram-se inalterados em todos os grupos