RESUMEN
Objective To study the effect of irbesartan combined with spironolactone on chronic heart failure and its effect on cardiac function.Methods 60 cases of patients with chronic heart failure treated in our hospital from February 2015 to February 2016 were randomly divided into the control group and the observation group, 30 cases in each group.The control group was treated with conventional therapy, the observation group was treated with irbesartan and spironolactone.The clinical efficacy, cardiac function indexes,blood pressure,heart rate,serum BNP and hs-CRP levels were observed in the 2 groups.Results After treatment, the total effective rate of the observation group was 86.67%(28/30)compared with the control group 63.33%(19/30), and the difference was statistically significant(P<0.05);cardiac function was improved in the two groups compared with before treatment, but the improvement in the observation group was more obvious[LVDd(52.33±4.92)mm vs(59.46±5.57)mm, LVSd(40.24±4.13)mm vs(46.95±4.87)mm, LVEF(48.62±7.13)% vs(42.41±6.65)%], the difference was statistically significant(P<0.05);Blood pressure and heart rate were decreased in the two groups before treatment, but the observation group decreased more significantly[diastolic pressure(75.36±3.54)mmHg vs(85.47±4.09)mmHg, systolic pressure(130.65±8.74)mmHg vs(139.22±9.35)mmHg, heart rate(76.72±10.56)times/min vs(82.59±11.34)times/min], the difference was statistically significant(P<0.05);the levels of BNP and hs-CRP in the two groups were lower than before treatment, but the observation group decreased more significantly[BNP(1.71±0.34)ng/mL vs(2.48±0.57)ng/mL,hs-CRP(6.26±1.03)μg/mL vs(8.79±1.12)μg/mL,the difference was statistically significant(P<0.05).Conclusion Irbesartan combine spironolactone treat with chronic heart failure have reliable curative effect, and it can effectively improve the patient's heart function, delay the development of the disease.
RESUMEN
Objective To compare the efficacy of domestic low-dose versus conventional-dose clopidogrel for patients with unstable angina pectoris (UAP). Methods A total of 206 UAP patients were randomly assigned to low-dose clopidogrel (50 mg/day) as treatment group and conventional-dose clopidogrel (75 mg/day) as control group. Treatment continued for 12 months to observe the extent of alleviating angina and major adverse cardiac events (MACE). Results The numbers of markedly effective, effective, ineffective and worse patients were 56(52.8%), 22 (20.8%), 11(10.4%) and 17(16.0%) in treatment group, and those were 52(51.0%), 20 (19.6%), 12(11.8%) and 18(17.7%) in control group (all P>0. 05). There was death in 3 cases, non-fatal myocardial infarction in 2 cases in treatment group, and death in 4 cases, non-fatal myocardial infarction in 2 cases in control group (χ~2 =0. 620, P>0. 05). Low-dose group had a lower incidence of adverse reactions. Conclusions The efficacy of low-dose clopidogrel for patients with UAP is not inferior to conventional-dose, and the safety is well.
RESUMEN
With the development of modern medical model,higher requirements are raised on medical humanity quality education.Based on the analysis and comparison of the current situation in terms of the set up of the course,course arrangement,teaching method and teaching strength,the author raises the solution of strengthening the medical students’humanity quality.