RESUMEN
Objective To investigate the clinical curative effect of α-lipoic acid combined with lipid microsphere alprostadil in treating elderly early diabetic kidney disease .Methods One hundred and sixty-four cases of early diabetic kidney disease treated in this hospital from January 2014 to January 2016 were selected and randomly divided into the experimental group and the control group according to the random number table method ,82 cases in each group .The control group was given lipid microsphere alpros-tadil ,while on this basis the experimental group was added with α-lipoic acid .The various biochemical indexes ,clinical efficacy and subcutaneous bruising ,fundus event occurrence were compared between the two groups .Results The levels of U-RBP and NAG after treatment in the two groups were significantly decreased compared with before treatment ,the difference was statistically sig-nificant (P<0 .05) .Although other indicators such as serum Scr ,BUN ,CysC andβ2-MG had different degrees of decline ,but the difference was not statistically significant (P>0 .05) .The effective rate in the experimental group was 91 .46% ,which was signifi-cantly higher than 78 .05% in the control group ,the difference was statistically significant (P<0 .05) .Subcutaneous bruising and fundus events in the experiment group had the increasing trend ,but the difference between the two groups had no statistical signifi-cance (P>0 .05) .Conclusion α-lipoic acid combined with lipid microsphere alprostadil in treating elderly early diabetic kidney dis-ease can better improve glomerular and renal tubular function .