Clinical analysis on 18 cases of adenoid cystic carcinoma of nasal cavity and sinuses / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To explore the clinical characteristics and treatment effect of adenoid cystic carcinoma in nasal cavity and sinuses.@*METHOD@#Sixteen of all 18 cases of adenoid cystic carcinoma of nasal cavity and sinuses were performed operation and radiotherapy. Other 2 cases were performed radiotherapy.@*RESULT@#Eighteen cases of patients were followed up for 5 years. Eight patients with early stage had no death. Five in 10 cases of advanced patients died, one case was out of following-up. In 11 of high differentiation group, 1 case died. In 7 of lower differentiation group, 4 cases died, 1 case lost.@*CONCLUSION@#Adenoid cystic carcinomas of nasal cavity and sinuses are distinct clinicopathological category and the clinical symptoms are noncharacteristic. Paying attention to the differential diagnosis and promoting related knowledge can help to avoid misdiagnosis. The prognosis is related to pathological category and clinical stage. High stage and high invasion of adenoid cystic carcinoma lead to poor prognosis.

Clinical analysis on 14 cases with malignant melanoma in nasal cavity and sinus / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the effect of treatment on malignant melanoma in nasal cavity and paranasal sinus.@*METHOD@#Fourteen patients with malignant melanoma in nasal cavity and paranasal sinus were retrospectively analyzed from 1995 to 2002, including clinical presentation, diagnosis, treatment and follow-up data.@*RESULT@#Thirteen patients were followed up, the survival rates of 3 and 5 years were 42.9% and 21.4% respectively.@*CONCLUSION@#Sinonasal malignant melanoma has an aggressive behavior and easy recurrence. Early diagnosis, radical operation and postoperative radiotherapy could improve the survival rate.

Comparing between CAUP and UPPP in treatment of OSAHS / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To evaluate the prospective effect of CAUP and applying midline partial glossectomy with UPPP in the treatment of OSAHS.@*METHOD@#One hundred OSAHS patients were distributed into two groups averagely. The patients of the two groups had CAUP and midline partial glossectomy respectively. All patients were followed-up 6 months and 12 months after operation and carried out using PSG every time.@*RESULT@#Therapeutic effect was evaluated by standard of Hangzhou (2002). In general, in 6 months, curative effect was excellent in 41 patients of the group of CAUP, good in 8 patients with effect, bed effect in 1 patients; in 12 months, it was excellent in 28 patients, good in 13 patients, bed in 9 patients. In 6 months, the curative effect the other group were excellent in 44 patients, good in 5 patients, bed in 1 patients; In 12 months, it was excellent in 43 patients , good in 6 patients, bed in 1 patients. In 6 month, the results showed that the effect of the two methods was similar (P > 0.05), but in 12 months the effect of group of CAUP was better than the other obviously (P < 0.01).@*CONCLUSION@#This operation could enlarge the narrow area of palatopharyngeal cavity effectively and decrease postoperative complications. It's a safe effective and acceptable surgical procedure.

Study on effect of celecoxib on CNE-2Z cell lines in human nasopharyngeal carcinoma / 重庆医科大学学报

Objective:To study the growth inhibition and potential mechanisms of celecoxib on nasopharyngeal carcinoma CNE-2Z cell lines.Methods:The effect of celecoxib on the growth of CNE-2Z cells was evaluated by MTT assay.The expressions of proliferating cell nuclear antigen(PCNA)and cyclooxygenase-2(COX-2)were assessed by immunocytochemistry method.Cell cycle was measured by Flow cytometry(FCM).Results:Celecoxib inhibited the proliferation of CNE-2Z cells in dosage and time dependent manner.The cell cycle was arrested in G0/G1 phase in CNE-2Z cells treated with celecoxib;Immunocytochemistry showed that the expressions of PCNA and C0X-2 decreased after incubated with celecoxib for 48 hours.Conclusion:The expression of COX-2 is found in CNE-2Z cell lines.The growth of CNE-2Z cell 1ines can be inhibited by celecoxib.Celecoxib may be used as chemotherapeutic agent for nasopharyngeal carcinoma.