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Objective To evaluate the synergistic effect of Baoxinkang on chronic heart failure ( CHF) rats by observing the effect of the combination of Baoxinkang and conventional medicine intervention on cardiac function and adenylate metabolism. Methods Sixty Sprague-Dawley rats were randomly divided into 6 groups, namely sham-operation group, model group, Baoxinkang group ( Baoxinkang 1 020 mg/kg) , conventional medicine intervention group (metoprolol 10 mg/kg, captopril 5 mg/kg, and digoxin 0.022 5 mg/kg), combination group 1 ( conventional medicine intervention + Baoxinkang 1 020 mg/kg) , and combination group 2 ( conventional medicine intervention + trimetazidine 10 mg/kg) . Abdominal aora was constricted to establish CHF rat model. The rats except for the sham-operation group and model group were given the corresponding medicine according to the experimental design for 6 weeks. Echocardiography ( ECHO) was performed to evaluate the cardiac function of rats. High performance liquid chromatography was utilized to investigate the contents of myocardiac adenylate of adenosine triphosphate ( ATP) , adenosine diphosphate ( ADP) , adenosine monophosphate (AMP) . Total adenylate nucleotide pool (TAN) was equal to ATP+ADP+AMP, energy charge (EC) was equal to ( ATP+0.5 ×ADP) /TAN. Results The results of ECHO showed that the heart size was reduced, left ejection fraction and cardiac output were increased in the combination group 1 compared with the model group and conventional medicine intervention group. The levels of ATP, TAN, and EC were significantly increased, whereas the levels of ADP and AMP were decreased in the combination group 1 (P0.05) . Conclusion Baoxinkang may have some synergistic effect on the improvement of CHF rat cardiac energy metabolism disorder treated by conventional medicine.
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[Objective] To observe the preventive effect and mechanism of heat-clearing and toxicity-removing therapy for the treatment of acute coronary syndrome (ACS), and to explore the relationship of ACS with inflammation. [Methods] Fifty five ACS patients were randomized into 2 groups:41 patients in group A were treated with Sanhuang Tablets (mainly composed of Radix et Rhizoma Rhei, Radix Scutellariae and Rhizoma Coptidis) p.o., 4 tablets one time, twice a day, and a routine treatment for anticoagulation, anti-platelet aggregation and anti-myocardial ischemia; 14 patients in group B were given routine treatment for anticoagulation, anti-platelet aggregation and anti-myocardial ischemia. The treatment course lasted 2 weeks. After treatment, improvement in symptoms such as chest pain, chest distension, short breath, palpitation, fever, spontaneous sweating, insomnia, lassitude, aversion to cold and cold limbs was compared between group A and group B by scoring method. Meanwhile, inflammatory indicators in the two groups were also observed before and after treatment. [Results] The decrease in symptom scores, as well as the decrease in blood C-reactive protein (CRP) , tumor necrosis factor a (TNF-?) and interleukin 6 (IL-6) , was obvious in group A than that in group B (P
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Objective To explore the relationship of apolipoprotein E(ApoE) and its gene polymorphism with phlegm and blood stasis syndrome in patients with coronary heart disease(CHD).Methods Ninety-seven qualified CHD patients involving phlegm syndrome(PS),blood-stasis syndrome(BSS),and phlegm and blood stasis syndrome(PBSS) were adopted.Thirty-five healthy volunteers were enrolled into the control group.Serum ApoE level was examined in all of the subjects,and their whole blood DNA were extracted for the detection of ApoE gene polymorphism by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Correlation analysis of the data was performed with SPSS11.0 software.Results The difference of diabetes mellitus,smoking,low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) was significant between CHD patients and healthy volunteers(P
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Objective To explore the relationship between acute coronary syndrome(ACS) and inflammation , and to observe the short-term effect of Xiangdan Injection(XI) in treating ACS and on inflammatory markers.Methods One hundred and twenty cases of ACS were randomized into two groups: 90 cases in treatment group and 30 in control group. All of the patients received the routine treatment, and the treatment group treated with XI additionally. The therapeutic effect was observed and plasma contents of inflammatory markers such as C-reactive protein (CRP), interleukin 6 (IL-6) and tumor necrosis factor ?(TNF-?) were detected before and after treatment.Results The effect of treatment group was better than that of the control group(P
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Objective To study the correlation of multiple factors with phlegm blood-stasis syndrome(PBSS) of coronary heart disease(CHD),and to explore the objective evidence for the clinical research.Methods A total of 135 cases was enrolled,which were divided into PBSS group(N=87) and non-PBSS group(N=48).Meanwhile,28 healthy volunteers served as the normal control.Five aspects including symptom scoring,hazard factor,basic laboratory examination,inflammatory factors and the result of coronarography were compared in the three groups.Results PBSS was the dominated syndrome of CHD.Symptom score in PBSS was higher.The analysis results of hazard factors of CHD showed that the body weight index,hypertension and the abnormal level of blood lipid were closely related with PBSS of CHD.The incidence of PBSS of CHD had a close relationship with the increased levels of total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C) in blood lipid examination.Of the inflammatory factors,C-reactive protein(CRP),tumor necrosis factor ?(TNF-?),interleukin 6(IL-6),soluble CD40 ligand(SCD40L) and intercellular adhesion molecule 1(ICAM-1) levels were closely related with PBSS of CHD.The pathological changes of coronary artery of PBSS involved multiple vessels,and were severe.Conclusion Phlegm blood-stasis syndrome of coronary heart disease is relevant with multiple factors.
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Objective To assess the therapeutic effect and safety of Chinese medicine with the actions of activating blood and removing stasis in the treatment of acute coronary syndrome(ACS)patients.Methods Sixty-six patients with ACS were randomly assigned to the control group,the Danshen Injection(DI) group and the DI combined with Chuanxiongzine Injection(CI) group.All of the three groups received antithrombotic therapy besides the corresponding medicine according to the experimental design.The therapeutic effect and safety of the three groups were observed and compared after treatment.Results The hemorheology of ACS patients in the three groups was improved(P