Study of Tiopronin combine Penicillamine to treated in rat model with hepatolenticular degeneration / 临床神经病学杂志

Objective To study the effects of Tiopronin(MPO)combine Penicillamine(PCA)on the copper metabolism and function of liver in rats model with hepatolenticular degeneration.Methods To copy hepatolenticular degeneration model rats with copper overloaded diet.Divide the models into groups HLD control,MPO,PCA and MPO+PCA,and interfere with the propotional drugs.To investigate the concentration changes of the lalanine aminotransferase(ALT),spartate amino transferase(AST),total protein(TP),albumin(ALB),liver copper and 24 h urine copper in each group.Results The concentrations of liver copper and 24 h urine copper in HLD control group and each group with drugs intervention were significantly higher than those in normal control group(all P