Responses of vasopressin release in patients with cardiopulmonary bypass anesthetized with enflurane and morphine

Changes in plasma level of arginine vasopressin (AVP), arterial pressure, and urine flow were studied before, during and after cardiopulmonary bypass (CPB) in 11 patients with congenital heart disease. Anesthesia was induced with thiopental sodium (3-5 mg/kg) and was maintained with enflurane (1.0-1.5%), 50% N2O in O2 and morphine (0.5 mg/kg). Concentration of plasma AVP increased slightly from 3.8 +/- 1.5 pg/ml after induction and increased 3-fold after sternotomy. Plasma AVP level increased to 132 +/- 26 pg/ml and 218 +/- 54 pg/ml after 5 and 60 min on CPB, respectively. When the circulation returned to normal, plasma AVP level decreased gradually but was still significantly higher at 24 hr (13.4 +/- 2.5 pg/ml). Marked osmolar diuresis was induced with mannitol in the priming solution used during the CPB: increases in urine flow, Na excretion and osmolar clearance. Possible mechanisms of marked increase in AVP release and differences of AVP responses during CPB reported by other investigators are discussed.

Changes of Heart Rate, Bolld Pressure, and Respiratory Rate after Ethanol Administration in the Flushing and Non-Flushing Men / 대한마취과학회지

Cardiovascular respons follwing ethanol ingeation was conapared in two groups of male college studenta; 20 who ahowed visble facial flushing and 25 whe showed on flushing. Ethanol was administered as 25% Korean liquor (Kumbokju) a dose of 2ml per kg body weight, the heart rate, blood pressure and respiratory rate were measured. The reaults areas follows. The heart rate after ethanol ingestion increased significantly in both flushing and non-flushing groups. However, the degree of the heart rate increased in the flushing group was aignificantly higher than that in the non-flushing group. The blood pressure was decreased significantly from 40minutes after ethanol ingestion in both groups. Howyer, the flushing group showed higher systolic pressure, and lower diastalic pressure and mean arterial pressure than the non-flushing group. The reapiratory rate following ethanol administration was increased in the flushing group but decreased in the non-flishing group when compared with the resting respiratory rate. The results clearly indicate that a signifcant difference in cardiovascular resoponrses to ethanol exists the flushing and non-flushing groups. The flushing group shows a greater tachycardia and greater fall in. mean arterial pressure followig ethanol ingestion than the non-flushing group.

Effect of Acute Alcohol Intoxication on the Hematocrit and Glutathione Levels in the Rat Blood / 대한마취과학회지

Ethyl alcohol is believed to inhibit the secretion of antidiuretic hormone (ADH) from the neurohypohysis, and an increase in urinary volume and reduction in the extracellular fluid volume may follow. In the case of acute alcohol intoxication, the red cells may be exposed. to the increasing level of the blood alcohol, and are in danger of being oxidized and/or hemolysed, for which the blood glutathione may exert a protective action. The aim of this study is to elucidate the acute effect of alcohol on the hematocrit, assuming that the decreased secretion of ADH will result in an increased value of the hematocrit, and also the change of oxidized glutathione (GSSG) and reduced glutatbione (GSH) of the blood following by the adminstration of alcohol. Albino rats were used throughout the experiment, and a rat was given 50% ethyl alcohol in the dose of l. 5 ml per 100 gm of body weight by the oral intubation. In all the alcohol administered cases, the rat immediately following the intubation became comatose and no voluntary effort to intake food or water was observed for at least twenty hours. The rat was sacrificed first by a strong blow on the head and the thorax was immediately opened. The blood sample for both hematocrit and glutathione was drawn from the thoracic cavity with the heart puncture if necessary after cutting the pulmonary and carotid arteries. The experiment was performed at 1,3,6,12 and 24 hours after the alcohol administration, and hematocrit was determined by the conventional hematocrit centrifuge and reader. The blood GSH was measured by the method of Ellman, and GSSG was measured by the method described by Dohan and Woodward. Controls were set which received the same amount of distilled water in place of alcohol.