RESUMEN
Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system and its lesions are multiple in time as well as space.We experienced a case of a 14-year-old-girl with dysphagia, paresthesia and headache. Brain MRI scans demonstrated high signal intensities on T2-weighted images at the medulla and upper cervical cord. Acute disseminated encephalomyelitis was diagnosed and methylprednisolone pulse therapy was done. After 6 months she re-experienced diplopia, ophthalmoplegia and other neurological symptoms. There were increased signal intensities on T2-weighted image at the tegmentum, periaqueduct and hypothalamus in follow-up brain MRI. Finally, a diagnosis of multiple sclerosis was made. Methylprednisolone pulse therapy was started and she then recovered without any neurologic symptoms and signs. We report a case of multiple sclerosis in a 14-year- old-girl who was confirmed by clinical courses and serial MRIs.
Asunto(s)
Encéfalo , Sistema Nervioso Central , Trastornos de Deglución , Enfermedades Desmielinizantes , Diagnóstico , Diplopía , Encefalomielitis Aguda Diseminada , Estudios de Seguimiento , Cefalea , Hipotálamo , Imagen por Resonancia Magnética , Metilprednisolona , Esclerosis Múltiple , Manifestaciones Neurológicas , Oftalmoplejía , ParestesiaRESUMEN
PURPOSE: The pertussis vaccines are divided into whole-cell vaccine and acellular vaccine. Purified component acellular pertussis vaccine, originally developed in Japan, has been used for primary immunization series in Korea since 1984. We performed this study to evaluate the prevalence of pertussis antibodies following vaccination with acellular pertussis vaccine. METHODS: We randomized 80 children who were immunized according to vaccine schedules including less than 2 month-old infants at Department of Pediatrics, Catholic University Medical College from February 1995 to October 1995. We measured agglutination titers of children by bacterial agglutination test. RESULTS: 1) The age distribution ranged from 5 days to 7 years old, the mean age was 14.5+/- 12.8 months and male to female ratio was 1:1. 2) Only 23 cases (28.8%) of the 80 cases were positive results. 3) Among 7 infants who were less than 2 months-old and were not immunized, 5 infants (71.4%) were seropositive. 4) There was no significant difference in positive rates among age groups which include 2 to 6 months age group, 7 to 18 months age group, and older than 18 months age group. CONCLUSIONS: The prevalence of pertussis positive rates is only 28.8% and there was no difference among age groups.